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Simple emulsion technique as an innovative template for preparation of porous, spongelike poly(lactide-co-glycolide) microspheres with pore-closing capability

Title
Simple emulsion technique as an innovative template for preparation of porous, spongelike poly(lactide-co-glycolide) microspheres with pore-closing capability
Authors
Lee, YoungmeSah, Hongkee
Ewha Authors
사홍기
SCOPUS Author ID
사홍기scopus
Issue Date
2016
Journal Title
JOURNAL OF MATERIALS SCIENCE
ISSN
0022-2461JCR Link1573-4803JCR Link
Citation
vol. 51, no. 13, pp. 6257 - 6274
Publisher
SPRINGER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of this study was to develop a new oil-in-water emulsion template for the preparation of highly porous poly(lactide-co-glycolide) (PLGA) microspheres having a spongelike skeleton and a pore-closing functionality. A dispersed phase consisting of isopropyl formate and PLGA was emulsified in an aqueous phase. Ammonia was added toward this emulsion, in order to induce ammonolysis in the dispersed phase. Subsequently, isopropyl formate was broken into water-soluble isopropanol and formamide. As they functioned as anti-solvents against PLGA, microsphere hardening occurred. Also, their leaching into the aqueous phase led to the formation of highly porous, spongelike microspheres. The microsphere porosity was found to be controlled by adjusting isopropyl formate volume, PLGA type and concentration, ammonia volume, and ammonia-isopropyl formate molar ratio. When these dried microspheres were dispersed into an aqueous phase, the pores closed themselves autonomously. Herein, the self-closing capability of the microspheres was greatly influenced by microsphere Tg and the aqueous phase temperature. FITC-dextran and lysozyme were successfully encapsulated into the microspheres by simply equilibrating their aqueous solutions with the self-closing microspheres. In conclusion, the new emulsion template did not use either a halogenated organic solvent or conventional porogens. It did not require high-shear or high-energy mixing devices that must be used in the practice of most contemporary microencapsulation techniques. Despite these facts, this new technique was able to fabricate spongelike microspheres with an extremely high porosity and an outstanding pore-closing functionality.
DOI
10.1007/s10853-016-9923-6
Appears in Collections:
약학대학 > 약학과 > Journal papers
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