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Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae
- Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae
- Lee, Jihye; Han, Chulkyeong; Lee, Tae Gu; Chin, Jungwook; Choi, Hyukjae; Lee, Wonjae; Paik, Man Jeong; Won, Dong Hwan; Jeong, Gyusang; Ko, Jaeyoung; Yoong, Yeo Joon; Nam, Sang-Jip; Fenical, William; Kang, Heonjoong
- Ewha Authors
- 윤여준; 남상집
- SCOPUS Author ID
- 윤여준; 남상집
- Issue Date
- Journal Title
- TETRAHEDRON LETTERS
- vol. 57, no. 18, pp. 1997 - 2000
- Streptomonospora sp.; Nocardiopsis sp.; alpha-Pyrone; Anti-inflammatory activity
- PERGAMON-ELSEVIER SCIENCE LTD
- SCI; SCIE; SCOPUS
- Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively, were isolated from marine sediments collected off shore near La Jolla, California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 1D and 2D NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an alpha-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC50 value of 13 mu M. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophilic genus Streptomonospora. (C) 2016 Elsevier Ltd. All rights reserved.
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