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Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae

Title
Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae
Authors
Lee, JihyeHan, ChulkyeongLee, Tae GuChin, JungwookChoi, HyukjaeLee, WonjaePaik, Man JeongWon, Dong HwanJeong, GyusangKo, JaeyoungYoong, Yeo JoonNam, Sang-JipFenical, WilliamKang, Heonjoong
Ewha Authors
윤여준남상집
SCOPUS Author ID
윤여준scopus; 남상집scopus
Issue Date
2016
Journal Title
TETRAHEDRON LETTERS
ISSN
0040-4039JCR Link
Citation
vol. 57, no. 18, pp. 1997 - 2000
Keywords
Streptomonospora sp.Nocardiopsis sp.alpha-PyroneAnti-inflammatory activity
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively, were isolated from marine sediments collected off shore near La Jolla, California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 1D and 2D NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an alpha-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC50 value of 13 mu M. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophilic genus Streptomonospora. (C) 2016 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.tetlet.2016.03.084
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자연과학대학 > 화학·나노과학전공 > Journal papers
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