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Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea

Title
Prevalence of antineuronal antibodies in patients with encephalopathy of unknown etiology: Data from a nationwide registry in Korea
Authors
Byun, Jung-IckLee, Soon-TaeJung, Keun-HwaSunwoo, Jun-SangMoon, JangsupKim, Tae-JoonLim, Jung-AhKim, SoyunKim, Do-YongHan, Su-HyunJang, HyeminSuh, Hong IlCho, A-HyunKim, Dong WookShin, Jung-WonKoo, Yong SeoChoi, Woo ChanLee, Woong-WooChoi, NariKim, SeongheonNam, HyunwooKoo, Dae LimKim, MinahLim, Byung ChanChae, Jong-HeeKim, Ki JoongJeon, DaejongPark, Kyung-IlJung, Ki-YoungKim, ManhoChu, KonLee, Sang Kun
Ewha Authors
문장섭
Issue Date
2016
Journal Title
JOURNAL OF NEUROIMMUNOLOGY
ISSN
0165-5728JCR Link1872-8421JCR Link
Citation
vol. 293, pp. 34 - 38
Keywords
AutoimmuneEncephalopathyAutoimmune synaptic antibodyClassic paraneoplastic antibodyPrevalence
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We aimed to evaluate the prevalence of antineuronal antibodies in a nationwide cohort of patients with encephalopathy of unknown etiology. We screened 1699 patients with idiopathic encephalopathy who were referred from 70 hospitals across Korea for autoimmune synaptic and classic paraneoplastic antibodies. Those with cerebellar degeneration, sensory polyneuropathy or other paraneoplastic syndromes without encephalopathy were not included in this study. One-hundred and four patients (6.12%) had antibody-associated autoimmune encephalopathy. Autoimmune synaptic antibodies were identified in 89 patients (5.24%) and classic paraneoplastic antibodies were identified in 16 patients (0.94%). The patients with antibody-associated autoimmune encephalopathy comprised a small but significant portion of the total number of patients with encephalopathy of unknown cause. (C) 2016 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jneuroim.2016.02.002
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연구기관 > 의과학연구소 > Journal papers
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