Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오구택 | * |
dc.date.accessioned | 2016-08-27T04:08:04Z | - |
dc.date.available | 2016-08-27T04:08:04Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-18373 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218136 | - |
dc.description.abstract | The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (Sirt1) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study, we demonstrate that metformin upregulates Igfbp-2 expression through the AMPK-Sirt1-PPAR alpha cascade pathway. In the liver of high fat diet, ob/ob, and db/db mice, Igfbp-2 expression was significantly decreased compared to the expression levels in the wild-type mice (p < 0.05). Upregulation of Igfbp-2 expression by metformin administration was disrupted by gene silencing of Ampk and Sirt1, and this phenomenon was not observed in Ppar alpha-null mice. Notably, activation of IGF-1 receptor (IGF-1R)dependent signaling by IGF-1 was inhibited by metformin. Finally, when compared to untreated type 2 diabetes patients, the metformin-treated diabetic patients showed increased IGFBP-2 levels with diminished serum IGF-1 levels. Taken together, these findings indicate that IGFBP-2 might be a new target of metformin action in diabetes and the metformin-AMPK-Sirt1-PPA alpha-IGFBP-2 network may provide a novel pathway that could be applied to ameliorate metabolic syndromes by controlling IGF-1 bioavailability. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states | * |
dc.type | Article | * |
dc.relation.volume | 6 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | SCIENTIFIC REPORTS | * |
dc.identifier.doi | 10.1038/srep23665 | * |
dc.identifier.wosid | WOS:000372700100001 | * |
dc.identifier.scopusid | 2-s2.0-84961669709 | * |
dc.author.google | Kang, Hye Suk | * |
dc.author.google | Cho, Ho-Chan | * |
dc.author.google | Lee, Jae-Ho | * |
dc.author.google | Oh, Goo Taeg | * |
dc.author.google | Koo, Seung-Hoi | * |
dc.author.google | Park, Byung-Hyun | * |
dc.author.google | Lee, In-Kyu | * |
dc.author.google | Choi, Hueng-Sik | * |
dc.author.google | Song, Dae-Kyu | * |
dc.author.google | Im, Seung-Soon | * |
dc.contributor.scopusid | 오구택(7007056663) | * |
dc.date.modifydate | 20240123094756 | * |