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dc.contributor.author오구택*
dc.date.accessioned2016-08-27T04:08:04Z-
dc.date.available2016-08-27T04:08:04Z-
dc.date.issued2016*
dc.identifier.issn2045-2322*
dc.identifier.otherOAK-18373*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/218136-
dc.description.abstractThe anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (Sirt1) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study, we demonstrate that metformin upregulates Igfbp-2 expression through the AMPK-Sirt1-PPAR alpha cascade pathway. In the liver of high fat diet, ob/ob, and db/db mice, Igfbp-2 expression was significantly decreased compared to the expression levels in the wild-type mice (p < 0.05). Upregulation of Igfbp-2 expression by metformin administration was disrupted by gene silencing of Ampk and Sirt1, and this phenomenon was not observed in Ppar alpha-null mice. Notably, activation of IGF-1 receptor (IGF-1R)dependent signaling by IGF-1 was inhibited by metformin. Finally, when compared to untreated type 2 diabetes patients, the metformin-treated diabetic patients showed increased IGFBP-2 levels with diminished serum IGF-1 levels. Taken together, these findings indicate that IGFBP-2 might be a new target of metformin action in diabetes and the metformin-AMPK-Sirt1-PPA alpha-IGFBP-2 network may provide a novel pathway that could be applied to ameliorate metabolic syndromes by controlling IGF-1 bioavailability.*
dc.languageEnglish*
dc.publisherNATURE PUBLISHING GROUP*
dc.titleMetformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states*
dc.typeArticle*
dc.relation.volume6*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.journaltitleSCIENTIFIC REPORTS*
dc.identifier.doi10.1038/srep23665*
dc.identifier.wosidWOS:000372700100001*
dc.identifier.scopusid2-s2.0-84961669709*
dc.author.googleKang, Hye Suk*
dc.author.googleCho, Ho-Chan*
dc.author.googleLee, Jae-Ho*
dc.author.googleOh, Goo Taeg*
dc.author.googleKoo, Seung-Hoi*
dc.author.googlePark, Byung-Hyun*
dc.author.googleLee, In-Kyu*
dc.author.googleChoi, Hueng-Sik*
dc.author.googleSong, Dae-Kyu*
dc.author.googleIm, Seung-Soon*
dc.contributor.scopusid오구택(7007056663)*
dc.date.modifydate20240123094756*


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