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Orai1 and STIM1 in ER/PM junctions: Roles in pancreatic cell function and dysfunction

Title
Orai1 and STIM1 in ER/PM junctions: Roles in pancreatic cell function and dysfunction
Authors
Son A.Park S.Shin D.M.Muallem S.
Ewha Authors
박성희
SCOPUS Author ID
박성희scopus
Issue Date
2016
Journal Title
American Journal of Physiology - Cell Physiology
ISSN
0363-6143JCR Link
Citation
vol. 310, no. 6, pp. C414 - C422
Keywords
ERJunctionsPancreasPMSignaling
Publisher
American Physiological Society
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Membrane contact sites (MCS) are critical junctions that form between the endoplasmic reticulum (ER) and membranes of various organelles, including the plasma membrane (PM). Signaling complexes, including mediators of Ca2+ signaling, are assembled within MCS, such as the ER/PM junction. This is most evident in polarized epithelial cells, such as pancreatic cells. Core Ca2+ signaling proteins cluster at the apical pole, the site of inositol 1,4,5-trisphosphate-mediated Ca2+ release and Orai1/transient receptor potential canonical-mediated store-dependent Ca2+ entry. Recent advances have characterized the proteins that tether the membranes at MCS and the role of these proteins in modulating physiological and pathological intracellular signaling. This review discusses recent advances in the characterization of Ca2+ signaling at ER/PM junctions and the relation of these junctions to physiological and pathological Ca2+ signaling in pancreatic acini. © 2016 the American Physiological Society.
DOI
10.1152/ajpcell.00349.2015
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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