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Effect of trans-fatty acids on lipid metabolism: Mechanisms for their adverse health effects

Title
Effect of trans-fatty acids on lipid metabolism: Mechanisms for their adverse health effects
Authors
Kwon, Youngjoo
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2016
Journal Title
FOOD REVIEWS INTERNATIONAL
ISSN
8755-9129JCR Link1525-6103JCR Link
Citation
vol. 32, no. 3, pp. 323 - 339
Keywords
Adverse health effectlipid metabolismpartially hydrogenated oilstrans-fatty acids
Publisher
TAYLOR & FRANCIS INC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Partially hydrogenated oils (PHOs), the major dietary source of trans-fatty acids (TFAs), are widely used in processed foods due to their stability and desirable texture. However, scientific evidence linking TFA intake and the high risk of coronary heart diseases led the US Food and Drug Administration (FDA) to declare that PHOs could no longer be generally recognized as safe for use in foods. Fatty acids (FAs) are incorporated into cellular membranes, thereby altering membrane fluidity. FAs also directly bind to and modulate nuclear receptors, resulting in the regulation of gene transcription. By means of such effects, TFAs may alter the function and responses of many types of cells. TFAs may be incorporated into body lipids, oxidized, and converted into longer and more unsaturated FAs as naturally occurring cis-FAs but with different efficiency. Furthermore, they might affect the metabolism of naturally occurring cis-FAs, contributing to alteration in body FA profile. Therefore, it is important to assess their absorption, metabolism, disposition, and effect on the metabolism of other lipids to estimate their health effects. This review examines the metabolic fate of dietary TFAs. In addition, their effects on lipid and cholesterol metabolisms are discussed to elucidate the potential mechanisms involved in their adverse health effects.
DOI
10.1080/87559129.2015.1075214
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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