View : 65 Download: 0

Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With I-123-FP-CIT SPECT

Title
Loss of Nigral Hyperintensity on 3 Tesla MRI of Parkinsonism: Comparison With I-123-FP-CIT SPECT
Authors
Bae, Yun JungKim, Jong-MinKim, EunheeLee, Kyung MiKang, Seo YoungPark, Hyun SooKim, Kyeong JoonKim, Young EunOh, Eung SeokYun, Ji YoungKim, Ji SeonJeong, Hye-JinJeon, BeomseokKim, Sang Eun
Ewha Authors
윤지영
SCOPUS Author ID
윤지영scopusscopus
Issue Date
2016
Journal Title
MOVEMENT DISORDERS
ISSN
0885-3185JCR Link1531-8257JCR Link
Citation
vol. 31, no. 5, pp. 684 - 692
Keywords
Parkinson's diseasemultiple system atrophyprogressive supranuclear palsymagnetic resonance imaging
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
BackgroundThe aim of this study was to investigate whether 3 Tesla susceptibility-weighted imaging can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) and to assess the concordance between the loss of nigral hyperintensity on 3 Tesla susceptibility-weighted imaging and the nigrostriatal dopaminergic degeneration indicated by I-123-2-carbomethoxy-3-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. MethodsConsecutive subjects with suspected parkinsonism were included, and clinical diagnosis was solidified during clinical follow-up. Two blinded neuroradiologists interpreted the nigral hyperintensity on susceptibility-weighted imaging. The performance of susceptibility-weighted imaging for detection of nigral hyperintensity loss was estimated on the basis of the clinical diagnosis and compared with single photon emission computerized tomography results. ResultsThe study included 210 subjects (126 PD, 11 MSA, 11 PSP patients, 26 healthy controls, 36 disease controls). The presence or absence of nigral hyperintensity was accurately visualized in 112 PD, 7 MSA, and 11 PSP patients and 53 controls. We identified 16 false-negative cases and 11 false-positive cases. The sensitivity and specificity of susceptibility-weighted imaging were 88.8% and 83.6%, respectively. The concordance rate between susceptibility-weighted imaging and single photon emission computerized tomography was 86.2%. ConclusionsThe loss of nigral hyperintensity on susceptibility-weighted imaging suggested nigrostriatal dopaminergic degeneration in a large portion of patients with parkinsonism, which was indicated by I-123-2-carbomethoxy-3-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computerized tomography. In consideration of false-negative and -positive cases, well-designed imaging protocols should be introduced to improve the performance of nigral hyperintensity imaging. (c) 2016 International Parkinson and Movement Disorder Society
DOI
10.1002/mds.26584
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE