Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.contributor.author | 창동신 | * |
dc.contributor.author | 한아름 | * |
dc.contributor.author | 우현애 | * |
dc.date.accessioned | 2016-08-27T04:08:03Z | - |
dc.date.available | 2016-08-27T04:08:03Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.issn | 1976-3786 | * |
dc.identifier.other | OAK-16665 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/218121 | - |
dc.description.abstract | A new cytoprotective compound, 1-[(4S)-3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]-ethanone (1) was isolated from the flower buds of Tussilago farfara L. (Compositae), together with eight known compounds, 3,4-dicaffeoyl isoquinic acid (2), trans-cinnamic acid (3), 4-hydroxyacetophenone (4), 4,5-dicaffeoylquinic acid methyl ester (5), 3,5-dicaffeoylquinic acid methyl ester (6), 4-hydroxybenzoic acid (7), isoquercetrin (8), and ligucyperonol (9). Compounds 2-4 were found in this plant for the first time. The isolates 1-9, were tested for their cytoprotective activities against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells. Among them, 1 and 3 showed significant cytoprotective activities as determined by MTT assay and lactate dehydrogenase leakage, indicating their possibility as the potent cytoprotective agents. The structure of 1 was determined by spectroscopic data analysis including 1D- and 2D-NMR experiments, and its absolute configuration was elucidated by a circular dichroism. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOC KOREA | * |
dc.subject | Tussilago farfara | * |
dc.subject | Compositae | * |
dc.subject | Phenolic compound | * |
dc.subject | Cytoprotection | * |
dc.subject | Oxidative stress | * |
dc.title | Identification of cytoprotective constituents of the flower buds of Tussilago farfara against glucose oxidase-induced oxidative stress in mouse fibroblast NIH3T3 cells and human keratinocyte HaCaT cells | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 39 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 474 | * |
dc.relation.lastpage | 480 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/s12272-016-0730-z | * |
dc.identifier.wosid | WOS:000374297100004 | * |
dc.identifier.scopusid | 2-s2.0-84961216322 | * |
dc.author.google | Kang, Unwoo | * |
dc.author.google | Park, Jiyoung | * |
dc.author.google | Han, Ah-Reum | * |
dc.author.google | Woo, Mi Hee | * |
dc.author.google | Lee, Je-Hyun | * |
dc.author.google | Lee, Sang Kook | * |
dc.author.google | Chang, Tong-Shin | * |
dc.author.google | Woo, Hyun Ae | * |
dc.author.google | Seo, Eun Kyoung | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 창동신(7404726037) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.contributor.scopusid | 우현애(8068619500) | * |
dc.date.modifydate | 20240215164922 | * |