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Safety and immunogenicity of influenza vaccine among HIV-infected adults: Conventional vaccine vs. intradermal vaccine

Title
Safety and immunogenicity of influenza vaccine among HIV-infected adults: Conventional vaccine vs. intradermal vaccine
Authors
Seo, Yu BinLee, JacobSong, Joon YoungChoi, Hee JungCheong, Hee JinKim, Woo Joo
Ewha Authors
최희정
SCOPUS Author ID
최희정scopus
Issue Date
2016
Journal Title
HUMAN VACCINES & IMMUNOTHERAPEUTICS
ISSN
2164-5515JCR Link2164-554XJCR Link
Citation
vol. 12, no. 2, pp. 478 - 484
Keywords
HIVinfluenza vaccineintradermal vaccineimmunogenicitysafety
Publisher
TAYLOR & FRANCIS INC
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Several studies have reported poor immune responses to conventional influenza vaccines in HIV-infected individuals. This study sought to elicit more potent immunogenicity in HIV-infected adults using an intradermal vaccine compared with a conventional intramuscular vaccine. This multicenter, randomized, controlled, open-label study was conducted at 3 university hospitals during the 2011/2012 pre-influenza season. Three vaccines were used in HIV-infected adults aged 18 - 60years: an inactivated intramuscular vaccine (Agrippal), a reduced-content intradermal vaccine (IDflu9g) and a standard-content intradermal vaccine (IDflu15g). Serum hemagglutination-inhibiting (HI) antibodies and INF- ELISpot assay were measured at the time of vaccination and 1month after vaccination. Adverse events were recorded for 7 d. A total of 28 Agrippal, 30 IDflu9g, and 28 IDflu15g volunteers were included in this analysis. One month after vaccination, the GMTs and differences in INF- ELISpot assay results were similar among the 3 groups. Seroprotection rates, seroconversion rates and mean fold increases (MFI) among the 3 groups were also similar, at approximately 80%, 50-60% and 2.5 - 10.0, respectively. All three vaccines satisfied the CHMP criteria for the A/H1N1 and A/H3N2 strains, but not those for the B strain. In univariate analysis, no demographic or clinical factors, including age, CD4+ T-cell counts, HIV viral load, ART status and vaccine type, were related to failure to achieve seroprotection. The three vaccines were all well-tolerated and all reported reactions were mild to moderate. However, there was a tendency toward a higher incidence of local and systemic reactions in the intradermal vaccine groups. The intradermal vaccine did not result in higher immunogenicity compared to the conventional intramuscular vaccine, even with increased antigen dose.
DOI
10.1080/21645515.2015.1076599
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의학전문대학원 > 의학과 > Journal papers
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