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dc.contributor.author이지수-
dc.date.accessioned2016-08-27T04:08:00Z-
dc.date.available2016-08-27T04:08:00Z-
dc.date.issued2016-
dc.identifier.issn1932-6203-
dc.identifier.otherOAK-16631-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/218107-
dc.description.abstractThe genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE.-
dc.languageEnglish-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.titleImputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume11-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitlePLOS ONE-
dc.identifier.doi10.1371/journal.pone.0150283-
dc.identifier.wosidWOS:000371274400117-
dc.identifier.scopusid2-s2.0-84960465745-
dc.author.googleKim, Kwangwoo-
dc.author.googleBang, So-Young-
dc.author.googleYoo, Dae Hyun-
dc.author.googleCho, Soo-Kyung-
dc.author.googleChoi, Chan-Bum-
dc.author.googleSung, Yoon-Kyoung-
dc.author.googleKim, Tae-Hwan-
dc.author.googleJun, Jae-Bum-
dc.author.googleKang, Young Mo-
dc.author.googleSuh, Chang-Hee-
dc.author.googleShim, Seung-Cheol-
dc.author.googleLee, Shin-Seok-
dc.author.googleLee, Jisoo-
dc.author.googleChung, Won Tae-
dc.author.googleKim, Seong-Kyu-
dc.author.googleChoe, Jung-Yoon-
dc.author.googleNath, Swapan K.-
dc.author.googleLee, Hye-Soon-
dc.author.googleBae, Sang-Cheol-
dc.contributor.scopusid이지수(14424388700)-
dc.date.modifydate20180329110821-


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