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IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer

Title
IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer
Authors
Kim, You-SunChoi, Jun-PyoKim, Min-HyePark, Han-KiYang, SejungKim, Youn-SeupKim, Tae BumCho, You-SookOh, Yeon-MokJee, Young-KooLee, Sang-DoKim, Yoon-Keun
Ewha Authors
김윤근최준표김민혜양세정
SCOPUS Author ID
김윤근scopusscopus; 김민혜scopus; 양세정scopus
Issue Date
2016
Journal Title
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
ISSN
2092-7355JCR Link2092-7363JCR Link
Citation
vol. 8, no. 3, pp. 198 - 205
Keywords
Extracellular vesiclesIgG sensitizationindoor dustasthmaCOPDlung cancer
Publisher
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Purpose: Recent experimental evidence shows that extracellular vesicles (EVs) in indoor dust induce neurtrophilic pulmonary inflammation, which is a characteristic pathology in patients with severe asthma and chronic obstructive pulmonary disease (COPD). In addition, COPD is known to be an important risk factor for lung cancer, irrespective of cigarette smoking. Here, we evaluated whether sensitization to indoor dust EVs is a risk for the development of asthma, COPD, or lung cancer. Methods: Serum IgG antibodies against dust EVs were measured in 90 healthy control subjects, 294 asthmatics, 242 COPD patients, and 325 lung cancer patients. Serum anti-dust EV IgG titers were considered high if they exceeded a 95 percentile value of the control subjects. Age-, gender-, and cigarette smoke-adjusted multiple logistic regression analyses were performed to determine odds ratios (ORs) for asthma, COPD, and lung cancer patients vs the control subjects. Results: In total, 4.4%, 13.6%, 29.3%, and 54.9% of the control, asthma, COPD, and lung cancer groups, respectively, had high serum anti-dust EV IgG titers. Adjusted multiple logistic regression revealed that sensitization to dust EVs (high serum anti-dust EV IgG titer) was an independent risk factor for asthma (adjusted OR, 3.3; 95% confidence interval [CI], 1.1-10.0), COPD (adjusted OR, 8.0; 95% CI, 2.0-32.5) and lung cancer (adjusted OR, 38.7; 95% Cl, 10.4-144.3). Conclusions: IgG sensitization to indoor dust EVs appears to be a major risk for the development of asthma, COPD, and lung cancer.
DOI
10.4168/aair.2016.8.3.198
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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