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Pharmacologic management of female sexual dysfunction

Title
Pharmacologic management of female sexual dysfunction
Authors
Yoon, HanaPark, Kwangsung
Ewha Authors
윤하나
SCOPUS Author ID
윤하나scopus
Issue Date
2016
Journal Title
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
ISSN
1975-8456JCR Link2093-5951JCR Link
Citation
vol. 59, no. 2, pp. 136 - 143
Keywords
FemaleSexual dysfunctionDrug therapy
Publisher
KOREAN MEDICAL ASSOC
Indexed
SCOPUS; KCI WOS scopus
Abstract
In female sexual dysfunction (FSD), psychological and contextual factors significantly influence organic components of sexual response and behavior. The hormonal environment also affects FSD. Therefore, a tailored medical approach to each individual's sexual symptom is inevitable. This paper reviews currently available pharmacological treatment of FSD including the most recent advances and future targets in pharmacotherapy. In hormonal therapies for FSD, efficacy of estrogens and androgens on the treatment of vaginal atrophy, low sexual desire, and small subsets of genital arousal disorder, respectively, have been demonstrated. However, we need more data regarding long-term safety. There are two non-hormonal agents approved by the US Food and Drug Administration. Flibanserin has shown marginal benefit over placebo for the treatment of hypoactive sexual desire disorder. Ospemifen has shown beneficial effect on vulvovaginal pain from hormone related atrophy although it requires a longer period data to assess safety in other female genital organs, such as uterus and ovaries. Controversies still remain regarding hormonal therapies for FSD. Besides, some of the developing drugs still require more reliable safety and efficacy data. However, pharmacologic treatment of FSD is a promising field yet to be explored.
DOI
10.5124/jkma.2016.59.2.136
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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