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The protective effects of alisol a 24-Acetate from alisma canaliculatum on ovariectomy induced bone loss in vivo

Title
The protective effects of alisol a 24-Acetate from alisma canaliculatum on ovariectomy induced bone loss in vivo
Authors
Hwang Y.-H.Kang K.-Y.Lee S.-J.Nam S.-J.Son Y.-J.Yee S.-T.
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2016
Journal Title
Molecules
ISSN
1420-3049JCR Link
Citation
vol. 21, no. 1
Keywords
Alisma canaliculatumAlisol a 24-acetateBone lossOsteoporosisRegulator t cellTraditional Korean medicine
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Alisma canaliculatum is a herb commonly used in traditional Korean medicine, and has been shown in scientific studies to have antitumor, diuretic hepatoprotective, and antibacterial effects. Recently, the anti-osteoclastogenesis of alisol A 24-acetate from Alisma canaliculatum was investigated in vitro. However, the influence of alisol A 24-acetate on osteoporosis in animals has not been investigated. The present study was undertaken to investigate the anti-osteoporotic effect of alisol A 24-acetate on bone mass in ovariectomized (OVX) mice and to identify the mechanism responsible for its effects. OVX mice were treated daily with 0.5 or 2 μg/g of alisol A 24-acetate for a period of six weeks. It was found that these administrations significantly suppressed osteoporosis in OVX mice and improved bone morphometric parameters. The serum estradiol, bone alkaline phosphatase levels, regulatory T/Th17 cell numbers were significantly increased by alisol A 24-acetate as compared with untreated OVX mice. In addition, TRAP activity was inhibited by alisol A 24-acetate in OVX mice. These results suggest alisol A 24-acetate effectively prevents bone loss in OVX mice, and that it can be considered a potential therapeutic for the treatment of postmenopausal osteoporosis.
DOI
10.3390/molecules21010074
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자연과학대학 > 화학·나노과학전공 > Journal papers
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