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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction
- Title
- Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction
- Authors
- Kang, In Sook; Fumiaki, Ikeno; Pyun, Wook Bum
- Ewha Authors
- 편욱범
- SCOPUS Author ID
- 편욱범
- Issue Date
- 2016
- Journal Title
- YONSEI MEDICAL JOURNAL
- ISSN
- 0513-5796
1976-2437
- Citation
- YONSEI MEDICAL JOURNAL vol. 57, no. 2, pp. 291 - 297
- Keywords
- Hypothermia; induced; myocardial infarction; myocardial reperfusion injury
- Publisher
- YONSEI UNIV COLL MEDICINE
- Indexed
- SCI; SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Mild therapeutic hypothermia of 32-35 degrees C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completely solved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewed rationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical application to the patients with acute myocardial infarction, lessons from current clinical trials and future directions.
- DOI
- 10.3349/ymj.2016.57.2.291
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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