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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction

Title
Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction
Authors
Kang, In SookFumiaki, IkenoPyun, Wook Bum
Ewha Authors
편욱범
SCOPUS Author ID
편욱범scopus
Issue Date
2016
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
0513-5796JCR Link1976-2437JCR Link
Citation
vol. 57, no. 2, pp. 291 - 297
Keywords
Hypothermiainducedmyocardial infarctionmyocardial reperfusion injury
Publisher
YONSEI UNIV COLL MEDICINE
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Mild therapeutic hypothermia of 32-35 degrees C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutic hypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completely solved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewed rationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical application to the patients with acute myocardial infarction, lessons from current clinical trials and future directions.
DOI
10.3349/ymj.2016.57.2.291
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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