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Natural killer cells in hepatitis C: Current progress

Title
Natural killer cells in hepatitis C: Current progress
Authors
Yoon, Joo ChunYang, Chang MoSong, YoukyongLee, Jae Myun
Ewha Authors
윤주천
SCOPUS Author ID
윤주천scopus
Issue Date
2016
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
ISSN
1007-9327JCR Link2219-2840JCR Link
Citation
vol. 22, no. 4, pp. 1449 - 1460
Keywords
Hepatitis C virusNatural killer cellAccessory cellVirus-host interactionImmune evasionAcute hepatitisChronic hepatitisTreatment response
Publisher
BAISHIDENG PUBLISHING GROUP INC
Indexed
SCIE; SCOPUS WOS
Abstract
Patients infected with the hepatitis C virus (HCV) are characterized by a high incidence of chronic infection, which results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The functional impairment of HCV-specific T cells is associated with the evolution of an acute infection to chronic hepatitis. While T cells are the important effector cells in adaptive immunity, natural killer (NK) cells are the critical effector cells in innate immunity to virus infections. The findings of recent studies on NK cells in hepatitis C suggest that NK cell responses are indeed important in each phase of HCV infection. In the early phase, NK cells are involved in protective immunity to HCV. The immune evasion strategies used by HCV may target NK cells and might contribute to the progression to chronic hepatitis C. NK cells may control HCV replication and modulate hepatic fibrosis in the chronic phase. Further investigations are, however, needed, because a considerable number of studies observed functional impairment of NK cells in chronic HCV infection. Interestingly, the enhanced NK cell responses during interferon-a-based therapy of chronic hepatitis C indicate successful treatment. In spite of the advances in research on NK cells in hepatitis C, establishment of more physiological HCV infection model systems is needed to settle unsolved controversies over the role and functional status of NK cells in HCV infection.
DOI
10.3748/wjg.v22.i4.1449
Appears in Collections:
의과대학 > 의학과 > Journal papers
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