Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문장섭 | - |
dc.date.accessioned | 2016-08-27T04:08:48Z | - |
dc.date.available | 2016-08-27T04:08:48Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | OAK-16356 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217985 | - |
dc.description.abstract | Objective To evaluate the seizure characteristics and outcome after immunotherapy in adult patients with autoimmune encephalitis (AE) and new-onset seizure. Methods Adult (age >= 18 years) patients with AE and new-onset seizure who underwent immunotherapy and were followed-up for at least 6 months were included. Seizure frequency was evaluated at 2-4 weeks and 6 months after the onset of the initial immunotherapy and was categorized as "seizure remission", "> 50% seizure reduction", or "no change" based on the degree of its decrease. Results Forty-one AE patients who presented with new-onset seizure were analysed. At 2-4 weeks after the initial immunotherapy, 51.2% of the patients were seizure free, and 24.4% had significant seizure reduction. At 6 months, seizure remission was observed in 73.2% of the patients, although four patients died during hospitalization. Rituximab was used as a second-line immunotherapy in 12 patients who continued to have seizures despite the initial immunotherapy, and additional seizure remission was achieved in 66.6% of them. In particular, those who exhibited partial response to the initial immunotherapy had a better seizure outcome after rituximab, with low adverse events. Conclusion AE frequently presented as seizure, but only 18.9% of the living patients suffered from seizure at 6 months after immunotherapy. Aggressive immunotherapy can improve seizure outcome in patients with AE. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Effect of Immunotherapy on Seizure Outcome in Patients with Autoimmune Encephalitis: A Prospective Observational Registry Study | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 11 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | PLOS ONE | - |
dc.identifier.doi | 10.1371/journal.pone.0146455 | - |
dc.identifier.wosid | WOS:000368628300021 | - |
dc.identifier.scopusid | 2-s2.0-84955440280 | - |
dc.author.google | Byun, Jung-Ick | - |
dc.author.google | Lee, Soon-Tae | - |
dc.author.google | Jung, Keun-Hwa | - |
dc.author.google | Sunwoo, Jun-Sang | - |
dc.author.google | Moon, Jangsup | - |
dc.author.google | Lim, Jung-Ah | - |
dc.author.google | Lee, Doo Young | - |
dc.author.google | Shin, Yong-Won | - |
dc.author.google | Kim, Tae-Joon | - |
dc.author.google | Lee, Keon-Joo | - |
dc.author.google | Lee, Woo-Jin | - |
dc.author.google | Lee, Han-Sang | - |
dc.author.google | Jun, Jinsun | - |
dc.author.google | Kim, Dong-Yub | - |
dc.author.google | Kim, Man-Young | - |
dc.author.google | Kim, Hyunjin | - |
dc.author.google | Kim, Hyeon Jin | - |
dc.author.google | Suh, Hong Il | - |
dc.author.google | Lee, Yoojin | - |
dc.author.google | Kim, Dong Wook | - |
dc.author.google | Jeong, Jin Ho | - |
dc.author.google | Choi, Woo Chan | - |
dc.author.google | Bae, Dae Woong | - |
dc.author.google | Shin, Jung-Won | - |
dc.author.google | Jeon, Daejong | - |
dc.author.google | Park, Kyung-Il | - |
dc.author.google | Jung, Ki-Young | - |
dc.author.google | Chu, Kon | - |
dc.author.google | Lee, Sang Kun | - |
dc.contributor.scopusid | 문장섭(55201409700) | - |
dc.date.modifydate | 20220112161912 | - |