Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 김관창 | * |
dc.date.accessioned | 2016-08-27T04:08:48Z | - |
dc.date.available | 2016-08-27T04:08:48Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1738-5520 | * |
dc.identifier.issn | 1738-5555 | * |
dc.identifier.other | OAK-16333 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217983 | - |
dc.description.abstract | Background and Objective: Failure of vascular smooth muscle apoptosis and inflammatory response in pulmonary arterial hypertension (PAH) is a current research focus. The goals of this study were to determine changes in select gene expressions in monocrotaline (MCT)-induced PAH rat models after human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) transfusion. Materials and Methods: The rats were separated into 3 groups i.e., control group (C group), M group (MCT 60 mg/kg), and U group (hUCB-MSCs transfusion) a week after MCT injection. Results: TUNEL assay showed that the U group had significantly lowered positive apoptotic cells in the lung tissues, as compared with the M group. mRNA of caspase-3, B cell leukemia/lymphoma (Bcl)-2, interleukin (IL) -6, tumor necrosis factor (TNF)-alpha and vascular endothelial growth factor (VEGF) in the lung tissues were greatly reduced at week 4 in the U group. Immunohistochemical staining of the lung tissues also demonstrated a similar pattern, with the exception of IL -6. The protein expression of caspase-3, Bcl-2 VEGF, IL -6, TNF-alpha and brain natriuretic peptide in the heart tissues were significantly lower in the U group, as compared with the M group at week 2. Furthermore, the protein expression of VEGF, IL -6 and BNP in the heart tissues were significantly lower in the U group at week 4. Collagen content in the heart tissues was significantly lower in the U group, as compared with M group at weeks 2 and 4, respectively. Conclusion: hUCB-MSCs could prevent inflammation, apoptosis and remodeling in MCT-induced PAH rat models. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC CARDIOLOGY | * |
dc.subject | Hypertension | * |
dc.subject | pulmonary | * |
dc.subject | Stem cell | * |
dc.subject | Vascular remodeling | * |
dc.subject | Inflammation | * |
dc.subject | Apoptosis | * |
dc.title | Changes in Caspase-3, B Cell Leukemia/Lymphoma-2, Interleukin-6, Tumor Necrosis Factor-alpha and Vascular Endothelial Growth Factor Gene Expression after Human Umbilical Cord Blood Derived Mesenchymal Stem Cells Transfusion in Pulmonary Hypertension Rat Models | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 79 | * |
dc.relation.lastpage | 92 | * |
dc.relation.journaltitle | KOREAN CIRCULATION JOURNAL | * |
dc.identifier.doi | 10.4070/kcj.2016.46.1.79 | * |
dc.identifier.wosid | WOS:000368568400011 | * |
dc.identifier.scopusid | 2-s2.0-84955296575 | * |
dc.author.google | Kim, Kwan Chang | * |
dc.author.google | Lee, Jae Chul | * |
dc.author.google | Lee, Hyeryon | * |
dc.author.google | Cho, Min-Sun | * |
dc.author.google | Choi, Soo Jin | * |
dc.author.google | Hong, Young Mi | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 김관창(36652690000) | * |
dc.date.modifydate | 20240415130647 | * |