Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.date.accessioned | 2016-08-27T04:08:47Z | - |
dc.date.available | 2016-08-27T04:08:47Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1043-4666 | * |
dc.identifier.issn | 1096-0023 | * |
dc.identifier.other | OAK-16305 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217975 | - |
dc.description.abstract | We previously isolated mesenchymal stromal cells from human tonsils (T-MSCs) and showed the potential of these cells to differentiate into the mesodermal lineage and acquire a follicular dendritic cell (FDC) phenotype under cytokine stimulation. Because these T-MSCs were originally isolated from inflamed tonsillar tissues, we were curious about their activation status in response to innate immune stimuli, such as Toll-like receptors (TLRs). Therefore, we analyzed the expression profile of TLRs in T-MSCs and stimulated the T-MSCs with TLR agonists. TLR3 stimuli induced C-C chemokine receptor type 6 expression in T-MSCs after 24 h. Furthermore, results from cytokine arrays showed increases in epithelial neutrophil-activating peptide-78/C-X-C motif chemokine (CXCL) 5, granulocyte chemotactic protein-2/CXCL6, growth-related oncogene-alpha/CXCL1, interleukin-8/CXCL8, and interferon gamma-induced protein-10/CXCL10. CD54 expression was also increased after TLR3 stimulation. However, co-culturing T-MSCs with human B cells did not induce B-cell proliferation. This suggests that TLR3 stimulates the differentiation of T-MSCs into FDC-like cells and induces chemokine secretion, possibly by recruiting C-X-C chemokine receptor 2-expressing immune cells. In addition, T-MSCs also appeared to exert immunomodulatory effects by inhibiting B-cell proliferation, possibly by down-regulating CD18. (C) 2015 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | * |
dc.subject | Toll-like receptors | * |
dc.subject | Tonsil-derived mesenchymal stromal cells | * |
dc.subject | CXCR2 | * |
dc.subject | CD54 | * |
dc.subject | B cells | * |
dc.title | Tonsil-derived mesenchymal stromal cells produce CXCR2-binding chemokines and acquire follicular dendritic cell-like phenotypes under TLR3 stimulation | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 73 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 225 | * |
dc.relation.lastpage | 235 | * |
dc.relation.journaltitle | CYTOKINE | * |
dc.identifier.doi | 10.1016/j.cyto.2015.02.028 | * |
dc.identifier.wosid | WOS:000368309600007 | * |
dc.author.google | Ryu, Jung-Hwa | * |
dc.author.google | Park, Minhwa | * |
dc.author.google | Kim, Bo-Kyung | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.author.google | Woo, So-Youn | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.date.modifydate | 20240118130224 | * |