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Intrathecal-specific glutamic acid decarboxylase antibodies at low titers in autoimmune neurological disorders

Title
Intrathecal-specific glutamic acid decarboxylase antibodies at low titers in autoimmune neurological disorders
Authors
Sunwoo, Jun -SangChu, KonByun, Jung-IckMoon, JangsupLim, Jung-AhKim, Tae-JoonLee, Soon-TaeJung, Keun-HwaPark, Kyung-IlJeon, DaejongJung, Ki-YoungKim, ManhoLee, Sang Kun
Ewha Authors
문장섭
Issue Date
2016
Journal Title
JOURNAL OF NEUROIMMUNOLOGY
ISSN
0165-5728JCR Link1872-8421JCR Link
Citation
vol. 290, pp. 15 - 21
Keywords
Glutamic acid decarboxylaseAutoantibodiesCerebrospinal fluidLimbic encephalitisImmunotherapy
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Autoantibodies to glutamic acid decarboxylase (Gad-Abs) are implicated in various neurological syndromes. The present study aims to identify intrathecal-specific GAD-Abs and to determine clinical manifestations and treatment outcomes. Nineteen patients had GAD-Abs in cerebrospinal fluid but not in paired serum samples. Neurological syndromes included limbic encephalitis, temporal lobe epilepsy, cerebellar ataxia, autonomic dysfunction, and stiff-person syndrome. Immunotherapy had beneficial effects in 57.1% of patients, and the patients with limbic encephalitis responded especially well to immunotherapy. Intrathecal-specific antibodies to GAD at low titers may appear as nonspecific markers of immune activation within the central nervous system rather than pathogenic antibodies causing neuronal dysfunction. (C) 2015 Elsevier B.V. All rights reserved.
DOI
10.1016/j.jneuroim.2015.11.012
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
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