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Intrathecal-specific glutamic acid decarboxylase antibodies at low titers in autoimmune neurological disorders
- Intrathecal-specific glutamic acid decarboxylase antibodies at low titers in autoimmune neurological disorders
- Sunwoo, Jun -Sang; Chu, Kon; Byun, Jung-Ick; Moon, Jangsup; Lim, Jung-Ah; Kim, Tae-Joon; Lee, Soon-Tae; Jung, Keun-Hwa; Park, Kyung-Il; Jeon, Daejong; Jung, Ki-Young; Kim, Manho; Lee, Sang Kun
- Ewha Authors
- Issue Date
- Journal Title
- JOURNAL OF NEUROIMMUNOLOGY
- JOURNAL OF NEUROIMMUNOLOGY vol. 290, pp. 15 - 21
- Glutamic acid decarboxylase; Autoantibodies; Cerebrospinal fluid; Limbic encephalitis; Immunotherapy
- ELSEVIER SCIENCE BV
- SCI; SCIE; SCOPUS
- Document Type
- Autoantibodies to glutamic acid decarboxylase (Gad-Abs) are implicated in various neurological syndromes. The present study aims to identify intrathecal-specific GAD-Abs and to determine clinical manifestations and treatment outcomes. Nineteen patients had GAD-Abs in cerebrospinal fluid but not in paired serum samples. Neurological syndromes included limbic encephalitis, temporal lobe epilepsy, cerebellar ataxia, autonomic dysfunction, and stiff-person syndrome. Immunotherapy had beneficial effects in 57.1% of patients, and the patients with limbic encephalitis responded especially well to immunotherapy. Intrathecal-specific antibodies to GAD at low titers may appear as nonspecific markers of immune activation within the central nervous system rather than pathogenic antibodies causing neuronal dysfunction. (C) 2015 Elsevier B.V. All rights reserved.
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