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Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease

Title
Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease
Authors
Jung, Jae-ChulLee, Yun-HeeKim, Sou HyunKim, Keuk-JunKim, Kyung-MiOh, SeikwanJung, Young-Suk
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2016
Journal Title
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN
1472-6882JCR Link
Citation
vol. 16
Keywords
LicoriceAlcohol-induced liver injuryGlutathioneTNF-alpha
Publisher
BIOMED CENTRAL LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative activity in tert-butyl hydroperoxide-induced oxidative liver damage. In this study, we evaluated the effect of licorice on chronic alcohol-induced fatty liver injury mediated by inflammation and oxidative stress. Methods: Raw licorice was extracted, and quantitative and qualitative analysis of its components was performed by using LC-MS/MS. Mice were fed a liquid alcohol diet with or without licorice for 4 weeks. Results: We have standardized 70 % fermented ethanol extracted licorice and confirmed by LC-MS/MS as glycyrrhizic acid (GA), 15.77 +/- 0.34 mu g/mg; liquiritin (LQ), 14.55 +/- 0.42 mu g/mg; and liquiritigenin (LG), 1.34 +/- 0.02 mu g/mg, respectively. Alcohol consumption increased serum alanine aminotransferase and aspartate aminotransferase activities and the levels of triglycerides and tumor necrosis factor (TNF)-alpha. Lipid accumulation in the liver was also markedly induced, whereas the glutathione level was reduced. All these alcohol-induced changes were effectively inhibited by licorice treatment. In particular, the hepatic glutathione level was restored and alcohol-induced TNF-alpha production was significantly inhibited by licorice. Conclusion: Taken together, our data suggests that protective effect of licorice against alcohol-induced liver injury may be attributed to its anti-inflammatory activity and enhancement of antioxidant defense.
DOI
10.1186/s12906-016-0997-0
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의학전문대학원 > 의학과 > Journal papers
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