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Change of health-related profiles after Imatinib cessation in chronic phase chronic myeloid leukemia patients

Title
Change of health-related profiles after Imatinib cessation in chronic phase chronic myeloid leukemia patients
Authors
Park, Joon SeongLee, Sung-EunJeong, Seong HyunJang, Eun-JungChoi, Mi-YeonKim, Hyeoung-JoonKim, Yeo-KyeoungKim, Sung-HyunZang, Dae YoungOh, SukjoongKoo, Dong HoeKim, HawkDo, Young RokKwak, Jae-YongKim, Jeong-AKim, Dae-YoungMun, Yeung-ChulLee, Won SikChang, Myung HeePark, JinnyKwon, Ji HyunKim, Dong-Wook
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2016
Journal Title
LEUKEMIA & LYMPHOMA
ISSN
1042-8194JCR Link1029-2403JCR Link
Citation
vol. 57, no. 2, pp. 341 - 347
Keywords
Chronic myeloid leukemiaimatinib cessationquality-of-life
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The aim of this study was to investigate the changes in health-related profiles including quality-of-life (HRQoL) in the chronic myeloid leukemia (CML) patients who discontinued imatinib (IM). An HRQoL survey composed of 43 parameters about IM-related adverse events (AEs), physical health-related and mental health-related was provided at baseline and 6 months post-discontinuation. A total of 55 patients with a sustained UMRD over 6 months were analyzed. Although the majority of IM-related AEs were significantly improved, unexpectedly pruritus and musculoskeletal pain worsen or newly develop in 29.1% and 21.8% of patients, respectively. The improvements in physical and mental health condition were variable in individual patients. In addition, rapid restorations of the hematological and biochemical parameters were observed. The results showed the changes of HRQoL and laboratory tests in treatment-off patients and the necessity of continuing physical and mental support for some patients in tyrosine kinase inhibitor (TKI)-off studies.
DOI
10.3109/10428194.2015.1049166
Appears in Collections:
의과대학 > 의학과 > Journal papers
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