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Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents
- Title
- Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents
- Authors
- Yoon, Seo Hee; Kim, Han Wool; Ahn, Jong Gyun; Kim, In Tae; Kim, Jong-Hyun; Kong, Kyoung Ae; Kim, Kyung-Hyo
- Ewha Authors
- 김경효; 김한울; 공경애; 안종균
- SCOPUS Author ID
- 김경효; 김한울; 공경애; 공경애; 안종균
- Issue Date
- 2016
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- ISSN
- 1011-8934
1598-6357
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE vol. 31, no. 1, pp. 73 - 79
- Keywords
- Hepatitis A Vaccines; Antibody Formation; Safety; Adolescent
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Although the overall incidence of hepatitis A in Korea has been decreasing, adolescents remain highly vulnerable to its outbreaks. This study was conducted to compare the immunogenicity and safety of three hepatitis A vaccines in Korean adolescents. Healthy anti-hepatitis A virus seronegative subjects aged 13 to 19 yr were randomized in three equal groups to receive two doses of Avaxim (TM), Epaxal (R), or Havrix (R), 6 to 12 months apart. Seroconversion rates one month after the first dose were 98%, 95%, and 93% for Avaxim (TM), Epaxal (R), and Havrix (R), respectively. Seroconversion rates reached 100% for all vaccine groups one month after the second dose. Anti-HAV geometric mean concentrations (GMCs) were 7,207.7 mIU/mL (95% CI, 6023.1-8684.7), 1,750.5 mIU/mL (95% CI, 1362.9-2248.3), and 1,953.5 mIU/mL (95% CI, 1459.4-2614.7) after two doses of Avaxim (TM), Epaxal (R), and Havrix (R) respectively. Avaxim (TM) was significantly more immunogenic than Epaxal (R) and Havrix (R), whereas there were no significant differences in antibody responses between Epaxal (R) and Havrix (R). Local and systemic solicited adverse events (AEs) were mostly of mild-to-moderate intensity and resolved within 5 days. No serious AEs were reported. In conclusion, all three vaccines are highly immunogenic and well-tolerated in Korean adolescents.
- DOI
- 10.3346/jkms.2016.31.1.73
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents.pdf(403.89 kB)
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