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Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents

Title
Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents
Authors
Yoon, Seo HeeKim, Han WoolAhn, Jong GyunKim, In TaeKim, Jong-HyunKong, Kyoung AeKim, Kyung-Hyo
Ewha Authors
김경효김한울공경애안종균
SCOPUS Author ID
김경효scopus; 김한울scopus; 공경애scopusscopus; 안종균scopus
Issue Date
2016
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link1598-6357JCR Link
Citation
vol. 31, no. 1, pp. 73 - 79
Keywords
Hepatitis A VaccinesAntibody FormationSafetyAdolescent
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Although the overall incidence of hepatitis A in Korea has been decreasing, adolescents remain highly vulnerable to its outbreaks. This study was conducted to compare the immunogenicity and safety of three hepatitis A vaccines in Korean adolescents. Healthy anti-hepatitis A virus seronegative subjects aged 13 to 19 yr were randomized in three equal groups to receive two doses of Avaxim (TM), Epaxal (R), or Havrix (R), 6 to 12 months apart. Seroconversion rates one month after the first dose were 98%, 95%, and 93% for Avaxim (TM), Epaxal (R), and Havrix (R), respectively. Seroconversion rates reached 100% for all vaccine groups one month after the second dose. Anti-HAV geometric mean concentrations (GMCs) were 7,207.7 mIU/mL (95% CI, 6023.1-8684.7), 1,750.5 mIU/mL (95% CI, 1362.9-2248.3), and 1,953.5 mIU/mL (95% CI, 1459.4-2614.7) after two doses of Avaxim (TM), Epaxal (R), and Havrix (R) respectively. Avaxim (TM) was significantly more immunogenic than Epaxal (R) and Havrix (R), whereas there were no significant differences in antibody responses between Epaxal (R) and Havrix (R). Local and systemic solicited adverse events (AEs) were mostly of mild-to-moderate intensity and resolved within 5 days. No serious AEs were reported. In conclusion, all three vaccines are highly immunogenic and well-tolerated in Korean adolescents.
DOI
10.3346/jkms.2016.31.1.73
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의과대학 > 의학과 > Journal papers
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