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dc.contributor.author창동신*
dc.contributor.author류재상*
dc.date.accessioned2016-08-27T04:08:43Z-
dc.date.available2016-08-27T04:08:43Z-
dc.date.issued2016*
dc.identifier.issn1477-0520*
dc.identifier.issn1477-0539*
dc.identifier.otherOAK-16242*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/217944-
dc.description.abstractWe have developed a straightforward and auxiliary-free synthetic route towards tBu-tubuphenylalanine (tBu-Tup) and tBu-epi-tubuphenylalanine (tBu-epi-Tup), which are the key components of tubulysins and their analogs. A Lewis acid-mediated diastereoselective Mukaiyama aldol reaction using silyl ketene acetal and N-Boc-L-phenylalaninal provided gamma-amino-beta-hydroxyl-alpha-methyl esters, which were deoxygenated to gamma-amino-alpha-methyl esters under Barton-McCombie deoxygenation conditions. Notably, the desired tBu-Tup and tBu-epi-Tup were obtained in good overall yields in four steps.*
dc.languageEnglish*
dc.publisherROYAL SOC CHEMISTRY*
dc.titleA concise synthesis of tubuphenylalanine and epi-tubuphenylalanine via a diastereoselective Mukaiyama aldol reaction of silyl ketene acetal*
dc.typeArticle*
dc.relation.issue3*
dc.relation.volume14*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage913*
dc.relation.lastpage919*
dc.relation.journaltitleORGANIC & BIOMOLECULAR CHEMISTRY*
dc.identifier.doi10.1039/c5ob02239h*
dc.identifier.wosidWOS:000368687600016*
dc.identifier.scopusid2-s2.0-84953889378*
dc.author.googlePark, Yunjeong*
dc.author.googleSim, Mikyung*
dc.author.googleChang, Tong-Shin*
dc.author.googleRyu, Jae-Sang*
dc.contributor.scopusid창동신(7404726037)*
dc.contributor.scopusid류재상(36081118200)*
dc.date.modifydate20231120165709*
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약학대학 > 약학과 > Journal papers
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