Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 창동신 | * |
dc.contributor.author | 류재상 | * |
dc.date.accessioned | 2016-08-27T04:08:43Z | - |
dc.date.available | 2016-08-27T04:08:43Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1477-0520 | * |
dc.identifier.issn | 1477-0539 | * |
dc.identifier.other | OAK-16242 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217944 | - |
dc.description.abstract | We have developed a straightforward and auxiliary-free synthetic route towards tBu-tubuphenylalanine (tBu-Tup) and tBu-epi-tubuphenylalanine (tBu-epi-Tup), which are the key components of tubulysins and their analogs. A Lewis acid-mediated diastereoselective Mukaiyama aldol reaction using silyl ketene acetal and N-Boc-L-phenylalaninal provided gamma-amino-beta-hydroxyl-alpha-methyl esters, which were deoxygenated to gamma-amino-alpha-methyl esters under Barton-McCombie deoxygenation conditions. Notably, the desired tBu-Tup and tBu-epi-Tup were obtained in good overall yields in four steps. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | A concise synthesis of tubuphenylalanine and epi-tubuphenylalanine via a diastereoselective Mukaiyama aldol reaction of silyl ketene acetal | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 913 | * |
dc.relation.lastpage | 919 | * |
dc.relation.journaltitle | ORGANIC & BIOMOLECULAR CHEMISTRY | * |
dc.identifier.doi | 10.1039/c5ob02239h | * |
dc.identifier.wosid | WOS:000368687600016 | * |
dc.identifier.scopusid | 2-s2.0-84953889378 | * |
dc.author.google | Park, Yunjeong | * |
dc.author.google | Sim, Mikyung | * |
dc.author.google | Chang, Tong-Shin | * |
dc.author.google | Ryu, Jae-Sang | * |
dc.contributor.scopusid | 창동신(7404726037) | * |
dc.contributor.scopusid | 류재상(36081118200) | * |
dc.date.modifydate | 20231120165709 | * |