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dc.contributor.author문영철-
dc.date.accessioned2017-08-28T08:05:24Z-
dc.date.available2017-08-28T08:05:24Z-
dc.date.issued2015-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/217938-
dc.description.abstractThis prospective observational study evaluated the efficacy and safety of long-term decitabine treatment in patients with myelodysplastic syndrome (MDS). Decitabine 20 mg/m(2)/day was administered intravenously for 5 consecutive days every 4 weeks to MDS patients in intermediate-1 or higher International Prognostic Scoring System (IPSS) risk categories. Active antimicrobial prophylaxis was given to prevent infectious complications. Overall response rate (ORR), overall survival (OS), progression-free survival (PFS), and time to response were evaluated, as were adverse events. The final analysis included 132 patients. IPSS risk was intermediate-2/high in 34.9% patients. The patients received a median of 5 cycles, with responders receiving a median of 8 cycles (range, 2-30). ORR was 62.9% (complete response [CR], 36; partial response [PR], 3; marrow complete response [mCR], 19; and hematologic improvement, 25). Among responders, 39% showed first response at cycle 3 or later. OS at 2 years was 60.9%, with 17% progressing to acute myeloid leukemia. PFS at 2 years was 51.0%. Patients achieving mCR showed comparable survival outcomes to those with CR/PR. With active antibiotic prophylaxis, febrile neutropenia events occurred in 61 of 1,033 (6%) cycles. Long-term decitabine treatment with antibiotic prophylaxis showed favorable outcomes in MDS patients, and mCR predicted favorable survival outcomes.-
dc.languageEnglish-
dc.publisherIMPACT JOURNALS LLC-
dc.subjectdecitabine-
dc.subjectlong-term treatment-
dc.subjectmyelodysplastic syndrome-
dc.titleA prospective, multicenter, observational study of long-term decitabine treatment in patients with myelodysplastic syndrome-
dc.typeArticle-
dc.relation.issue42-
dc.relation.volume6-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage44985-
dc.relation.lastpage44994-
dc.relation.journaltitleONCOTARGET-
dc.identifier.wosidWOS:000369908800068-
dc.identifier.scopusid2-s2.0-84953373584-
dc.author.googleJeong, Seong Hyun-
dc.author.googleKim, Yoo-Jin-
dc.author.googleLee, Je-Hwan-
dc.author.googleKim, Yeo-Kyeoung-
dc.author.googleKim, Soo Jeong-
dc.author.googlePark, Sung Kyu-
dc.author.googleDo, Young Rok-
dc.author.googleKim, Inho-
dc.author.googleMun, Yeung-Chul-
dc.author.googleKim, Hoon Gu-
dc.author.googleLee, Won Sik-
dc.author.googleYi, Hyeon Gyu-
dc.author.googleJoo, Young-Don-
dc.author.googleChoi, Chul Won-
dc.author.googleKim, Suk Ran-
dc.author.googleNa, Sang Min-
dc.author.googleJang, Jun Ho-
dc.contributor.scopusid문영철(7003363716)-
dc.date.modifydate20170601134020-


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