View : 29 Download: 0

Calreticulin mRNA expression and clinicopathological characteristics in acute myeloid leukemia

Title
Calreticulin mRNA expression and clinicopathological characteristics in acute myeloid leukemia
Authors
Park, SholhuiHuh, Hee JinMun, Yeung ChulSeong, Chu-MyongChung, Wha SoonChung, Hae-SunHuh, Jungwon
Ewha Authors
정화순성주명허정원문영철정혜선
SCOPUS Author ID
정화순scopus; 성주명scopus; 허정원scopus; 문영철scopus; 정혜선scopus
Issue Date
2015
Journal Title
CANCER GENETICS
ISSN
2210-7762JCR Link2210-7770JCR Link
Citation
vol. 208, no. 12, pp. 630 - 635
Keywords
CALRmRNAAMLMPNALL
Publisher
ELSEVIER SCIENCE INC
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Calreticulin, encoded by CALR, is a multifunctional protein with roles in calcium homeostasis and chaperoning molecular processes. This study aimed to evaluate calreticulin mRNA expression levels in acute myeloid leukemia (AML) compared with other hematologic malignancies, and to investigate the clinicopathological characteristics associated with expression in AML patients. The study group included 43 patients diagnosed with AML, 57 with other hematologic malignancies, and 21 benign hematologic conditions. CALR mRNA quantification using real-time polymerase chain reaction revealed it to be significantly higher in AML compared with other hematologic malignancies (P < 0.0001). There was no difference in CALR mRNA expression between AML subgroups by karyotype (P = 0.3201). No differences were found in age, white blood cell counts, platelet counts, bone marrow blast percentage, calcium, lactate dehydrogenase or CD34 expression rate between the high and low CALR groups (CALR mRNA >= 1.2 fold and <1.2 fold, respectively), although hemoglobin and sex differences were observed. Although statistically not significant, there was a trend that Relapse rate was lower (54.5% vs. 84.6%) (P = 0.1063) and disease-free survival was longer (22 months vs. 7 months) (P = 0.0784) in low CALR group, whereas overall survival was similar between the two groups (11 months and 8 months). The clinical relevance of CALR expression in AML remains to be clarified in a larger cohort.
DOI
10.1016/j.cancergen.2015.11.001
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE