Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희선 | * |
dc.date.accessioned | 2016-08-27T04:08:41Z | - |
dc.date.available | 2016-08-27T04:08:41Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 1976-9148 | * |
dc.identifier.issn | 2005-4483 | * |
dc.identifier.other | OAK-16189 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217918 | - |
dc.description.abstract | Oxidative stress activates several intracellular signaling cascades that may have deleterious effects on neuronal cell survival. Thus, controlling oxidative stress has been suggested as an important strategy for prevention and/or treatment of neurodegenerative diseases. In this study, we found that ginsenoside Rh1 inhibited hydrogen peroxide-induced reactive oxygen species generation and subsequent cell death in rat primary astrocytes. Rh1 increased the expression of phase antioxidant enzymes, such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1, superoxide dismutase-2, and catalase, that are under the control of Nrf2/ARE signaling pathways. Further mechanistic studies showed that Rh1 increased the nuclear translocation and DNA binding of Nrf2 and c-Jun to the antioxidant response element (ARE), and increased the ARE-mediated transcription activities in rat primary astrocytes. Analysis of signaling pathways revealed that MAP kinases are important in HO-1 expression, and act by modulating ARE-mediated transcriptional activity. Therefore, the upregulation of antioxidant enzymes by Rh1 may provide preventive therapeutic potential for various neurodegenerative diseases that are associated with oxidative stress. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | * |
dc.subject | Astrocytes | * |
dc.subject | Ginsenoside Rh1 | * |
dc.subject | Antioxidant enzyme | * |
dc.subject | MAPK-Nrf2 signaling | * |
dc.title | Protopanaxatriol Ginsenoside Rh1 Upregulates Phase II Antioxidant Enzyme Gene Expression in Rat Primary Astrocytes: Involvement of MAP Kinases and Nrf2/ARE Signaling | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 24 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 33 | * |
dc.relation.lastpage | 39 | * |
dc.relation.journaltitle | BIOMOLECULES & THERAPEUTICS | * |
dc.identifier.doi | 10.4062/biomolther.2015.129 | * |
dc.identifier.wosid | WOS:000367640100005 | * |
dc.identifier.scopusid | 2-s2.0-84952646799 | * |
dc.author.google | Jung, Ji-Sun | * |
dc.author.google | Lee, Sang-Yoon | * |
dc.author.google | Kim, Dong-Hyun | * |
dc.author.google | Kim, Hee-Sun | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.date.modifydate | 20240118140922 | * |