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Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct

Title
Factors related to prevalence, persistence, and incidence of depressive symptoms in mild cognitive impairment: vascular depression construct
Authors
Kim, SanghaWoo, Sook YoungKang, Hyo ShinLim, Shin WonChoi, Seong HyeMyung, WoojaeJeong, Jee HyangLee, YunhwanHong, Chang HyungKim, Jong HunNa, HaeRiCarroll, Bernard J.Kim, Doh Kwan
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2016
Journal Title
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
ISSN
0885-6230JCR Link1099-1166JCR Link
Citation
vol. 31, no. 7, pp. 818 - 826
Keywords
depressiondepressive symptommild cognitive impairmentrisk factorvascular depressionwhite matter hyperintensities
Publisher
WILEY-BLACKWELL
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Abstract
ObjectiveDepression is prevalent among elders with cognitive impairment. Cerebral white matter hyperintensities (WMH) have consistently been implicated in late-life depression and in cognitive impairment. This study aims to clarify the factors related to prevalence, persistence, and new onset of depressive symptoms in subjects with mild cognitive impairment (MCI). MethodsAs part of a multicenter prospective study, the Clinical Research Center for Dementia of South Korea (CREDOS) Study, we enrolled 590 subjects diagnosed with MCI and with no prior history of depression. Depressive symptoms were assessed by the Korean version of the Geriatric Depression Scale short form (SGDS-K) at baseline and at follow-up visits. Brain magnetic resonance imaging was performed at baseline to quantify WMH using a visual rating scale. ResultsThe baseline prevalence of clinically significant depressive symptoms (SGDS-K5) was 51.4%, and this feature was associated with younger age, lower educational achievement, and higher Clinical Dementia Rating Sum of Boxes (CDR-SB) scores. Persistence of depressive symptoms across the study period was significantly associated with baseline CDR-SB and depression scores. New onset of depression (SGDS-K8; incidence 15.7%) among subjects free of depressive symptoms (SGDS-K<5) at baseline was associated with severe deep subcortical, but not periventricular, WMH. ConclusionsIn patients with MCI aged 50years or older, depressive symptoms were highly prevalent. Cognitive status was closely related to both prevalence and persistence of depressive symptoms, while new onset of depression was associated with deep subcortical WMH severity in this MCI cohort. Our findings provide prospective evidence consistent with the vascular depression hypothesis. Copyright (c) 2015 John Wiley & Sons, Ltd.
DOI
10.1002/gps.4400
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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