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Single nucleotide polymorphisms in DKK3 gene are associated with prostate cancer risk and progression

Title
Single nucleotide polymorphisms in DKK3 gene are associated with prostate cancer risk and progression
Authors
Kim, Min SuLee, Ha NaKim, Hae JongMyung, Soon Chul
Ewha Authors
이하나
SCOPUS Author ID
이하나scopus
Issue Date
2015
Journal Title
INTERNATIONAL BRAZ J UROL
ISSN
1677-5538JCR Link1677-6119JCR Link
Citation
vol. 41, no. 5, pp. 869 - 897
Keywords
Biological MarkersGenetic VariationProstatic NeoplasmsPolymorphismSingle Nucleotide
Publisher
BRAZILIAN SOC UROL
Indexed
SCIE; SCOPUS WOS scopus
Abstract
We had investigated whether sequence variants within DKK3 gene are associated with the development of prostate cancer in a Korean study cohort. We evaluated the association between 53 single nucleotide polymorphisms (SNPs) in the DKK3 gene and prostate cancer risk as well as clinical characteristics (PSA, clinical stage, pathological stage and Gleason score) in Korean men (272 prostate cancer subjects and 173 benign prostate hyperplasia subjects) using unconditional logistic regression analysis. Of the 53 SNPs and 25 common haplotypes, 5 SNPs and 4 haplotypes were associated with prostate cancer risk (P= 0.02-0.04); 3 SNPs and 2 haplotypes were significantly associated with susceptibility to prostate cancer, however 2 SNPs and 2 haplotypes exhibited a significant protective effect on prostate cancer. Logistic analyses of the DKK3 gene polymorphisms with several prostate cancer related factors showed that several SNPs were significant; three SNPs and two haplotypes to PSA level, three SNPs and two haplotypes to clinical stage, nine SNPs and two haplotype to pathological stage, one SNP and one haplotypes to Gleason score. To the author's knowledge, this is the first report documenting that DKK3 polymorphisms are not only associated with prostate cancer but also related to prostate cancer-related factors.
DOI
10.1590/S1677-5538.IBJU.2014.0041
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의료원 > 의료원 > Journal papers
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