Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍영미 | * |
dc.date.accessioned | 2016-08-27T04:08:35Z | - |
dc.date.available | 2016-08-27T04:08:35Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1738-5520 | * |
dc.identifier.issn | 1738-5555 | * |
dc.identifier.other | OAK-16074 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217861 | - |
dc.description.abstract | In order to perform large-scale genetic studies of Kawasaki disease (KD) in Korea, the Korean Kawasaki Disease Genetics Consortium (KKDGC) was formed in 2008 with 10 hospitals: Since the establishment of KKDGC, there has been a collection of clinical data from a total of 1198 patients, and approximately 5 mL of blood samples per patient (for genomic deoxyribonucleic acid and plasma isolation), using a standard clinical data collection form and a nation-wide networking system for blood sample pick-up. In the clinical risk factor analysis using the collected clinical data of 478 KD patients, it was found that incomplete KD type, intravenous immunoglobulin (IVIG) non-responsiveness, and long febrile days are major risk factors for coronary artery lesions development, whereas low serum albumin concentration is an independent risk factor for IVIG non-responsiveness. In addition, we identified a KD susceptibility locus at 1p31, a coronary artery aneurysm locus (KCNN2 gene), and the causal variant in the C-reactive protein (CRP) promoter region, as determining the increased CRP levels in KD patients, by means of genome-wide association studies. Currently, this consortium is continually collecting more clinical data and genomic samples to identify the clinical and genetic risk factors via a single nucleotide polymorphism chip and exome sequencing, as well as collaborating with several international KD genetics teams. The consortium-based approach for genetic studies of KD in Korea will be a very effective way to understand the unknown etiology and causal mechanism of KD, which may be affected by multiple genes and environmental factors. | * |
dc.language | English | * |
dc.publisher | KOREAN SOC CARDIOLOGY | * |
dc.subject | Mucocutaneous lymph node syndrome | * |
dc.subject | Genome-wide association study | * |
dc.subject | Polymorphism | * |
dc.subject | single nucleotide | * |
dc.title | Consortium-Based Genetic Studies of Kawasaki Disease in Korea: Korean Kawasaki Disease Genetics Consortium | * |
dc.type | Review | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 45 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 443 | * |
dc.relation.lastpage | 448 | * |
dc.relation.journaltitle | KOREAN CIRCULATION JOURNAL | * |
dc.identifier.doi | 10.4070/kcj.2015.45.6.443 | * |
dc.identifier.wosid | WOS:000365465800001 | * |
dc.author.google | Lee, Jong-Keuk | * |
dc.author.google | Hong, Young Mi | * |
dc.author.google | Jang, Gi Young | * |
dc.author.google | Yun, Sin Weon | * |
dc.author.google | Yu, Jeong Jin | * |
dc.author.google | Yoon, Kyung Lim | * |
dc.author.google | Lee, Kyung-Yil | * |
dc.author.google | Kil, Hong-Rang|Korean Kawasaki Dis Genetics | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.date.modifydate | 20240415130647 | * |