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A Case Report of Urothelial Carcinoma With Combined Micropapillary and Plasmacytoid Morphology in the Urinary Bladder

Title
A Case Report of Urothelial Carcinoma With Combined Micropapillary and Plasmacytoid Morphology in the Urinary Bladder
Authors
Park, SanghuiCho, Min-SunKim, Kwang Hyun
Ewha Authors
조민선박상희김광현
SCOPUS Author ID
조민선scopus; 박상희scopus; 김광현scopus
Issue Date
2016
Journal Title
DIAGNOSTIC CYTOPATHOLOGY
ISSN
8755-1039JCR Link1097-0339JCR Link
Citation
vol. 44, no. 2, pp. 124 - 127
Keywords
urothelial carcinomamicropapillaryplasmacytoidbladderurine
Publisher
WILEY-BLACKWELL
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A case of combined micropapillary and plasmacytoid urothelial carcinoma (UC) of the urinary bladder is presented for a 74-year-old male who was admitted to the hospital with gross hematuria and multifocal papillary bladder tumors. Abdominal computed tomography showed a large enhancing mass on the left lateral and anterior wall of the urinary bladder, which was highly suspicious for extravesicular extension and focal extension of the anterior lesion to the pubic bone. In voided urine, cancer cells were scattered as micropapillae or nests as well as single cells on the low power view. On a higher power view, micropapillae or nests were composed of pleomorphic, high grade tumor cells with an inverted nuclear arrangement and with acinar structures occasionally identified. Single cells were discohesive and large with a thick cytoplasm and eccentrically located nuclei. Histologically, the tumor from the resected bladder showed diffusely infiltrating micropapillae or nests with a surrounding halo and dense singly-scattered plasmacytoid cells. Immunohistochemically, the cancer cells were positive for cytokeratin-7 and cytokeratin-20 but negative for S-100, leukocyte common antigen, and vimentin. At the time of radical cystectomy, severe adhesions and peritoneal metastases were found and the surgery was discontinued. The patient received systemic chemotherapy, but died of bladder cancer 14 months after surgery. (C) 2015 Wiley Periodicals, Inc.
DOI
10.1002/dc.23373
Appears in Collections:
의과대학 > 의학과 > Journal papers
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