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Spiroindole Alkaloids and Spiroditerpenoids from Aspergillus duricaulis and Their Potential Neuroprotective Effects

Title
Spiroindole Alkaloids and Spiroditerpenoids from Aspergillus duricaulis and Their Potential Neuroprotective Effects
Authors
Kwon, JaeyoungSeo, Young HyeLee, Jae-EunSeo, Eun-KyoungLi, ShenGuo, YuanqiangHong, Seung-BeomPark, So-YoungLee, Dongho
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2015
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link1520-6025JCR Link
Citation
vol. 78, no. 11, pp. 2572 - 2579
Publisher
AMER CHEMICAL SOC
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Six new spiroindole alkaloids (1-6) and two new spiroditerpenoids (7 and 8) were isolated from an EtOAc extract of Aspergillus duricaulis culture media together with five known compounds. The structures of the isolated compounds were elucidated by analysis of NMR and MS data, and the absolute configurations of compounds 1-8 were confirmed by CD spectroscopic methods. All isolated compounds were evaluated for their inhibition of beta-amyloid (A beta) aggregate-induced toxicity in PC12 cells and A beta aggregation. Compounds 8-11 efficiently protected PC12 cells against A beta aggregate-induced toxicity, but only compound 9 inhibited A beta aggregation. On the other hand, compounds 4 and 5 exhibited moderate inhibitory effects on A beta aggregation, but did not protect the cells from A beta aggregate-induced toxicity. Preincubating A beta monomers with compounds 4 and 5 rescued PC12 cells against A beta aggregate-induced toxicity by reducing neurotoxic A beta aggregates. Compound 9 inhibited both A beta aggregate-induced toxicity and A beta aggregation.
DOI
10.1021/acs,jnatprod.5b00508
Appears in Collections:
약학대학 > 약학과 > Journal papers
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