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Polymorphisms in period genes and bone response to hormone therapy in postmenopausal Korean women

Title
Polymorphisms in period genes and bone response to hormone therapy in postmenopausal Korean women
Authors
Kim, J.Kim, H.Ku, S-Y.Suh, C. S.Kim, J. H.Kim, J. G.
Ewha Authors
김종학
SCOPUS Author ID
김종학scopus
Issue Date
2016
Journal Title
CLIMACTERIC
ISSN
1369-7137JCR Link1473-0804JCR Link
Citation
vol. 19, no. 1, pp. 85 - 90
Keywords
Hormone therapybone mineral densityPERpolymorphismnon-responder
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective In this study, we aimed to explore the association between polymorphisms in the period (PER) gene and bone response to hormone therapy (HT) in postmenopausal Korean women.Methods The PER1 c.2284C>G, c.2247C>T, PER2 c.3731G>A, PER3 c.2592G>A, c.3083T>C polymorphisms, and PER3 54bp variable number of tandem repeats (VNTR) were analyzed in 509 postmenopausal Korean women who received HT. Bone mineral density (BMD) at the lumbar spine and femoral neck before and after 1 year of HT and serum levels of osteoprotegerin (OPG), soluble receptor activator of the nuclear factor-B ligand (sRANKL) and bone turnover markers were measured after 6 months of HT.Results The PER1 c.2884 C>G polymorphism and PER3 54bp VNTR were associated with annual percent changes in BMD of the femoral neck after 1 year of HT (p<0.05). Changes in BMD at the femoral neck in the non-CC genotype of the PER1 c.2884C>G polymorphism and in the 4-repeat homozygote of PER3 54bp VNTR were significantly lower than those in CC genotype and non-4-repeat homozygote, respectively. The PER1 c.2884C>G polymorphism was associated with the non-response (>3% BMD loss/year after HT) of HT. The non-CC genotype of the PER1 c.2884C>G polymorphism showed a 1.92-times higher risk of non-response at the lumbar spine and/or femoral neck (p=0.01) compared with the CC genotype. No significant changes in bone markers after 6 months of HT were noted according to the PER1 c.2884C>G polymorphism.Conclusions The PER1 c.2884C>G polymorphism may be associated with risk of non-response to HT in postmenopausal Korean women.
DOI
10.3109/13697137.2015.1115476
Appears in Collections:
의과대학 > 의학과 > Journal papers
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