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Unstable Body Mass Index and Progression to Probable Alzheimer's Disease Dementia in Patients with Amnestic Mild Cognitive Impairment

Title
Unstable Body Mass Index and Progression to Probable Alzheimer's Disease Dementia in Patients with Amnestic Mild Cognitive Impairment
Authors
Ye, Byoung SeokJang, Eun YoungKim, Seong YoonKim, Eun-JooPark, Sun AhLee, YunhwanHong, Chang HyungChoi, Seong HyeYoon, BoraYoon, Soo JinNa, Hae RiLee, Jae-HongJeong, Jee H.Kim, Hee JinNa, Duk L.Seo, Sang Won
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2015
Journal Title
JOURNAL OF ALZHEIMERS DISEASE
ISSN
1387-2877JCR Link1875-8908JCR Link
Citation
vol. 49, no. 2, pp. 483 - 491
Keywords
Alzheimer's diseaseamnestic mild cognitive impairmentbody mass indexdementiaprogression
Publisher
IOS PRESS
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background and Objective: We investigated the influence of body mass index (BMI) status at baseline and changes in BMI over a follow-up period on the development of dementia in amnestic mild cognitive impairment (aMCI) patients. Methods: The longitudinal data of 747 aMCI patients were used to investigate the relationships among baseline BMI status, subsequent changes in BMI (median follow-up duration: 1.6 years, interquartile range: 1.0-2.3 years), and risk of progression to probable Alzheimer's disease dementia (pADD). The aMCI patients were classified into underweight, normal weight, overweight, and obese subgroups, and further categorized into increased BMI, stable BMI, and decreased BMI subgroups during follow-up using a 4% mean annual change in BMI cut-off value. Results: Compared to the normal weight group, the underweight group had a higher risk of pADD (hazard ratio [HR]: 1.89, 95% confidence interval [CI]: 1.07-3.37) while the obese group had a lower risk (HR: 0.70, 95% CI: 0.49-0.999). After controlling for baseline BMI status, the decreased BMI (HR: 2.29, 95% CI: 1.41-3.72) and increased BMI (HR: 3.96, 95% CI: 2.62-6.00) groups were at increased risk of progression to pADD. Conclusions: Our findings suggested that underweight at baseline was associated with a higher risk of progression to pADD, while obesity at baseline predicted a lower risk. Furthermore, significant changes in BMI during the follow-up period reflected an increased risk of progression to pADD, regardless of BMI status at baseline.
DOI
10.3233/JAD-150556
Appears in Collections:
의과대학 > 의학과 > Journal papers
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