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The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment

Title
The neural correlates of motor intentional disorders in patients with subcortical vascular cognitive impairment
Authors
Kim, Geon HaSeo, Sang WonJung, KihyoKwon, Oh-HunKwon, HunkiKim, Jong HunRoh, Jee HoonKim, Min-JeongLee, Byung HwaYoon, Doo SangHwang, Jung WonLee, Jong MinJeong, Jee HyangYou, HeecheonHeilman, Kenneth M.Na, Duk L.
Ewha Authors
정지향김건하
SCOPUS Author ID
정지향scopus; 김건하scopus
Issue Date
2016
Journal Title
JOURNAL OF NEUROLOGY
ISSN
0340-5354JCR Link1432-1459JCR Link
Citation
vol. 263, no. 1, pp. 89 - 99
Keywords
Motor intentional disorderSubcortical vascular cognitive impairmentCortical thicknessTract-based spatial statistics
Publisher
SPRINGER HEIDELBERG
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Subcortical vascular cognitive impairment (SVCI) refers to cognitive impairment associated with small vessel disease. Motor intentional disorders (MID) have been reported in patients with SVCI. However, there are no studies exploring the neuroanatomical regions related to MID in SVCI patients. The aim of this study, therefore, was to investigate the neural correlates of MID in SVCI patients. Thirty-one patients with SVCI as well as 10 healthy match control participants were included. A "Pinch-Grip" apparatus was used to quantify the force control capabilities of the index finger in four different movement phases including initiation, development, maintenance, and termination. All participants underwent magnetic resonance imaging (MRI). Topographical cortical areas and white matter tracts correlated with the performances of the four different movement phases were assessed by the surface-based morphometry and tract-based spatial statistics analyses. Poorer performance in the maintenance task was related to cortical thinning in bilateral dorsolateral prefrontal, orbitofrontal and parietal cortices, while poorer performance in the termination task was associated with the disruption of fronto-parietal cortical areas as well as the white matter tracts including splenium and association fibers such as superior longitudinal fasciculus. Our study demonstrates that cortical areas and underlying white matter tracts associated with fronto-parietal attentional system play an important role in motor impersistence and perseveration in SVCI patients.
DOI
10.1007/s00415-015-7946-6
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의학전문대학원 > 의학과 > Journal papers
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