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Significance of calcium-sensing receptor expression in gastric cancer

Title
Significance of calcium-sensing receptor expression in gastric cancer
Authors
Tae, Chung HyunShim, Ki-NamKim, Hye InJoo, Yang-HeeLee, Joo-HoCho, Min-SunMoon, Chang MoKim, Seong-EunJung, Hye-KyungJung, Sung-Ae
Ewha Authors
정성애조민선정혜경이주호심기남김성은문창모태정현
SCOPUS Author ID
정성애scopus; 조민선scopus; 정혜경scopus; 이주호scopus; 심기남scopus; 김성은scopus; 문창모scopus; 태정현scopusscopus
Issue Date
2016
Journal Title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
ISSN
0036-5521JCR Link1502-7708JCR Link
Citation
vol. 51, no. 1, pp. 67 - 72
Keywords
calcium-sensing receptortumor suppressiontumor markersgastric cancer
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective. The calcium-sensing receptor (CaSR) is known to have differential expression in various carcinomas and normal tissues. It has been shown to be involved in carcinogenesis or tumor suppression. However, its role in gastric cancer remains unknown. This study was performed to determine the CaSR expression level in gastric cancer and non-tumor gastric tissues and to examine the related clinicopathological factors. Materials and methods. Thirty-one pairs of gastric cancer tissues and matched non-tumor gastric tissues were obtained from surgical tissues after gastrectomy. Using real-time polymerase chain reaction, we measured CaSR mRNA expression. We evaluated the association between CaSR mRNA expression and clinicopathological variables based on the downregulation or upregulation of CaSR mRNA expression in gastric cancer tissues compared to those of matched non-tumor gastric tissues. By immunohistochemistry, we confirmed CaSR expression levels in gastric cancer tissues. Results. Downregulation of CaSR mRNA was observed in 77.4% of gastric cancer tissues compared to their matched normal tissues. Downregulated CaSR was associated with a tendency for deeper invasion into the proper muscle (p = 0.028) and more advanced stage (II-IV; p = 0.012). Conclusion. We conclude that downregulation of CaSR may contribute to the prevention or suppression of tumor outgrowth.
DOI
10.3109/00365521.2015.1064993
Appears in Collections:
의과대학 > 의학과 > Journal papers
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