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Thrombus length discrepancy on dual-phase CT can predict clinical outcome in acute ischemic stroke
- Thrombus length discrepancy on dual-phase CT can predict clinical outcome in acute ischemic stroke
- Park, Mina; Kim, Kyung-eun; Shin, Na-Young; Lee, Seung-Koo; Lim, Soo Mee; Song, Dongbeom; Heo, Ji Hoe; Kim, Jin Woo; Oh, Se Won
- Ewha Authors
- 임수미; 신나영
- SCOPUS Author ID
- 임수미; 신나영
- Issue Date
- Journal Title
- EUROPEAN RADIOLOGY
- 0938-7994; 1432-1084
- vol. 26, no. 7, pp. 2215 - 2222
- Brain Infarction; Stroke; Neuroimaging; Tomography, X-Ray computed; Middle cerebral artery
- SCI; SCIE; SCOPUS
- The thrombus length may be overestimated on early arterial computed tomography angiography (CTA) depending on the collateral status. We evaluated the value of a grading system based on the thrombus length discrepancy on dual-phase CT in outcome prediction. Forty-eight acute ischemic stroke patients with M1 occlusion were included. Dual-phase CT protocol encompassed non-contrast enhanced CT, CTA with a bolus tracking technique, and delayed contrast enhanced CT (CECT) performed 40s after contrast injection. The thrombus length discrepancy between CTA and CECT was graded by using a three-point scale: G0 = no difference; G1 = no difference in thrombus length, but in attenuation distal to thrombus; G2 = difference in thrombus length. Univariate and multivariate analyses were performed to define independent predictors of poor clinical outcome at 3 months. The thrombus discrepancy grade showed significant linear relationships with both the collateral status (P = 0.008) and the presence of antegrade flow on DSA (P = 0.010) with good interobserver agreement (kappa = 0.868). In a multivariate model, the presence of thrombus length discrepancy (G2) was an independent predictor of poor clinical outcome [odds ratio = 11.474 (1.350-97.547); P =0.025]. The presence of thrombus length discrepancy on dual-phase CT may be a useful predictor of unfavourable clinical outcome in acute M1 occlusion patients. aEuro cent Early arterial phase CTA may underestimate thrombus length. aEuro cent Thrombus length discrepancy grade reflects collateral status or presence of antegrade flow. aEuro cent Outcome prediction may be better with thrombus length grade than collateral score.
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