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Comparison of diagnostic accuracy between endometrial curettage and pipelle aspiration biopsy in patients treated with progestin for endometrial hyperplasia: a Korean Gynecologic Oncology Group Study (KGOG 2019)

Title
Comparison of diagnostic accuracy between endometrial curettage and pipelle aspiration biopsy in patients treated with progestin for endometrial hyperplasia: a Korean Gynecologic Oncology Group Study (KGOG 2019)
Authors
Kim, Mi KyoungSeong, Seok JuLee, Taek SangKi, Kyung-DoLim, Myong CheolKim, Yun HwanKim, KidongJoo, Won Duk
Ewha Authors
김윤환
SCOPUS Author ID
김윤환scopus
Issue Date
2015
Journal Title
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
ISSN
0368-2811JCR Link1465-3621JCR Link
Citation
vol. 45, no. 10, pp. 980 - 982
Keywords
endometrial hyperplasiaprogesteroneLNG-IUSdilatation and curettageendometrial aspiration biopsy
Publisher
OXFORD UNIV PRESS
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A prospective multicenter trial has been started in Korea to evaluate the diagnostic accuracy of endometrial aspiration biopsy compared with dilatation and curettage in patients treated with progestin for endometrial hyperplasia. For conservative treatment of endometrial hyperplasia, orally administered progestins are most commonly used method with various treatment regimens and more recently, the levonorgestrel-releasing intrauterine system also has been used successfully to treat endometrial hyperplasia. However, there is no report about the accuracy of endometrial sampling during hormonal treatment for follow-up evaluation of endometrial hyperplasia. Patients with histologically confirmed endometrial hyperplasia are offered hormonal treatment with any one of the following three options: oral medroxyprogesterone acetate 10 mg/day for 14 days per cycle, continuous oral medroxyprogesterone acetate 10 mg/day or insertion of levonorgestrel-releasing intrauterine system. Histological surveillance is performed at 3 months or 6 months following initial treatment. Endometrial tissues are obtained via endometrial aspiration biopsy using a pipelle and dilatation and curettage. In the case of levonorgestrel-releasing intrauterine system, endometrial aspiration biopsy will be done with levonorgestrel-releasing intrauterine system in uterus and then, after the removal of levonorgestrel-releasing intrauterine system, dilatation and curettage will be done. The biopsy findings will be compared. The primary endpoint is to compare the pathological outcome of endometrial aspiration with dilatation and curettage. The secondary endpoint is the response rate with three types of progestin treatment at 6 months.
DOI
10.1093/jjco/hyv106
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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