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Clinical outcome and prognostic factors after salvage surgery for isolated regional squamous cell carcinoma recurrences
- Clinical outcome and prognostic factors after salvage surgery for isolated regional squamous cell carcinoma recurrences
- Chung, Eun-Jae; Lee, Sang-Hyo; Baek, So-Hye; Bae, Woo-Jin; Chang, Yong-Joon; Rho, Young-Soo
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- 1043-3074; 1097-0347
- vol. 37, no. 11, pp. 1612 - 1617
- head and neck cancer; recurrence; surgery; prognosis; mortality
- SCI; SCIE; SCOPUS
- Background. The purpose of this study was to evaluate the outcome and predictive factors for salvage surgery of isolated regional recurrences of head and neck squamous cell carcinoma. Methods. A retrospective study was conducted with 55 patients who were treated with surgery-based treatment. Results. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 61.8% and 60%, respectively. Extracapsular spread (ECS) was an independent factor associated with worse disease-specific survival. The patients who had advanced N classification, ECS, and in-field recurrence had a significantly worse OS rate, whereas those with an initial DFS time of 6 months or more experienced better outcomes. Conclusion. Salvage surgery for isolated regional recurrence resulted in an acceptable oncologic outcome and mortality. Successful surgical salvage is most probable in late recurrence (>= 6 months) patients with recurrent N1 stage tumors (no evidence of ECS) outside of the previous treatment field. (C) 2014 Wiley Periodicals, Inc.
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