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Clinical outcome and prognostic factors after salvage surgery for isolated regional squamous cell carcinoma recurrences

Title
Clinical outcome and prognostic factors after salvage surgery for isolated regional squamous cell carcinoma recurrences
Authors
Chung, Eun-JaeLee, Sang-HyoBaek, So-HyeBae, Woo-JinChang, Yong-JoonRho, Young-Soo
Ewha Authors
노영수
SCOPUS Author ID
노영수scopus
Issue Date
2015
Journal Title
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
ISSN
1043-3074JCR Link1097-0347JCR Link
Citation
vol. 37, no. 11, pp. 1612 - 1617
Keywords
head and neck cancerrecurrencesurgeryprognosismortality
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background. The purpose of this study was to evaluate the outcome and predictive factors for salvage surgery of isolated regional recurrences of head and neck squamous cell carcinoma. Methods. A retrospective study was conducted with 55 patients who were treated with surgery-based treatment. Results. The 5-year overall survival (OS) and disease-free survival (DFS) rates were 61.8% and 60%, respectively. Extracapsular spread (ECS) was an independent factor associated with worse disease-specific survival. The patients who had advanced N classification, ECS, and in-field recurrence had a significantly worse OS rate, whereas those with an initial DFS time of 6 months or more experienced better outcomes. Conclusion. Salvage surgery for isolated regional recurrence resulted in an acceptable oncologic outcome and mortality. Successful surgical salvage is most probable in late recurrence (>= 6 months) patients with recurrent N1 stage tumors (no evidence of ECS) outside of the previous treatment field. (C) 2014 Wiley Periodicals, Inc.
DOI
10.1002/hed.23799
Appears in Collections:
의과대학 > 의학과 > Journal papers
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