View : 48 Download: 0

Dose-dependency of dexamethasone on the analgesic effect of interscalene block for arthroscopic shoulder surgery using ropivacaine 0.5% A randomised controlled trial

Title
Dose-dependency of dexamethasone on the analgesic effect of interscalene block for arthroscopic shoulder surgery using ropivacaine 0.5% A randomised controlled trial
Authors
Woo, Jae HeeKim, Youn JinKim, Dong YeonCho, Sooyoung
Ewha Authors
김동연김윤진우재희
SCOPUS Author ID
김동연scopus; 김윤진scopus; 우재희scopus
Issue Date
2015
Journal Title
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
ISSN
0265-0215JCR Link1365-2346JCR Link
Citation
vol. 32, no. 9, pp. 650 - 655
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Indexed
SCIE; SCOPUS WOS scopus
Abstract
BACKGROUNDDexamethasone prolongs the duration of single-shot interscalene brachial plexus block (SISB). However, dose-dependency of dexamethasone as an adjuvant for SISB remains insufficiently understood.OBJECTIVEThe objective of this study is to evaluate the effect of different doses of dexamethasone on the duration of SISB using ropivacaine 0.5%.DESIGNA randomised, double-blind controlled trial.SETTINGSingle university tertiary care centre.PATIENTSOne hundred and forty-four patients scheduled for elective arthroscopic shoulder surgery were allocated randomly to one of four groups.INTERVENTIONSPatients received 12ml of ropivacaine 0.5% in 0.9% saline (control group), or containing dexamethasone 2.5, 5.0 or 7.5mg for SISB.MAIN OUTCOME MEASURESThe primary endpoint was the time to the first analgesic request. Pain scores and adverse effects were also assessed up to 48h postoperatively.RESULTSInclusion of dexamethasone 2.5, 5.0 and 7.5mg resulted in significant (P<0.001) increases in time to the first analgesic request by factors of 1.6, 2.2 and 1.8, respectively. The percentages of patients not requiring analgesics in the first 48h postoperatively with dexamethasone 0.0, 2.5, 5.0 and 7.5mg were 3, 22, 39 and 33%, respectively (P<0.001). There were no significant effects on pain scores or incidences of adverse effects.CONCLUSIONDexamethasone demonstrated significant beneficial dose-dependent effects on duration to the first analgesic request, the number of patients not requiring analgesics and analgesic use in the first 48h after SISB for arthroscopic shoulder surgery. There were no significant effects on pain scores or incidences of adverse effects.TRIAL REGISTRATIONthe trial was registered with the Clinical Trial Registry of Korea: https://cris.nih.go.kr/cris/index.jsp. Identifier: KCT0001078
DOI
10.1097/EJA.0000000000000213
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE