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Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS)

Title
Predictors of Clinical Progression of Subjective Memory Impairment in Elderly Subjects: Data from the Clinical Research Centers for Dementia of South Korea (CREDOS)
Authors
Hong, Yun JeongYoon, BoraShim, Yong S.Kim, Seon-OkKim, Hwa JungChoi, Seong HyeJeong, Jee HyangYoon, Soo JinYang, Dong WonLee, Jae-Hong
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2015
Journal Title
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
ISSN
1420-8008JCR Link1421-9824JCR Link
Citation
vol. 40, no. 42067, pp. 158 - 165
Keywords
Subjective memory impairmentMild cognitive impairmentAlzheimer's diseaseProgressionPredictors
Publisher
KARGER
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Background/Aims: The aims of this study were to determine baseline factors related to the progression of subjective memory impairment (SMI) in elderly subjects and to develop a new modeling scale to predict progression. Methods: Elderly subjects with SMI were recruited from the nationwide Clinical Research Centers for Dementia of South Korea (CREDOS) multicenter cohort and divided into two groups: (1) progressed to mild cognitive impairment or Alzheimer's disease or (2) stable without progression. Baseline clinical characteristics were compared between the groups, and the most relevant predictors of progression were assessed. A new modeling scale combining the predictors was developed. Results: In total, 129 subjects with SMI were analyzed. The follow-up duration was 0.5-4.7 years, and the median time to event was 3.64 years. The progressing group (n = 29) differed from the stable group (n = 100) in terms of baseline age, apolipoprotein E4 (APOE4) status, and some cognitive domains. Older age, a lower Mini-Mental State Examination recall score, APOE4 carrier, and a lower verbal delayed recall score were the most relevant predictors of progression, and a new modeling scale with these 4 predictors provided a better explanation of progression. Conclusion: SMI subjects with a higher risk of progression can be identified using a new modeling scale and might need further evaluations and more frequent follow-up. (C) 2015 S. Karger AG, Basel
DOI
10.1159/000430807
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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