View : 22 Download: 6

Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naive Newly Diagnosed Pediatric Epilepsy

Title
Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naive Newly Diagnosed Pediatric Epilepsy
Authors
Lee, Jung HwaKim, Song E.Park, Chang-hyunYoo, Jeong HyunLee, Hyang Woon
Ewha Authors
유정현이향운박창현
SCOPUS Author ID
유정현scopus; 이향운scopus; 박창현scopus
Issue Date
2015
Journal Title
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133JCR Link2314-6141JCR Link
Publisher
HINDAWI PUBLISHING CORPORATION
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Epilepsy patients often have cognitive dysfunction even at early stages of disease. We investigated the relationship between structural findings and neuropsychological status in drug-naive newly diagnosed pediatric epilepsy patients. Thirty newly diagnosed pediatric epilepsy patients and 25 healthy control subjects aged 7 similar to 16 years were enrolled, who were assessed by the Korean version of the Wechsler Intelligence Scale for Children (K-WISC-III), the Stroop test, and the trail making test (TMT). Optimized voxel-based morphometry (VBM) was performed for both Gray Matter (GM) and White Matter (WM) volumes. Lower performance levels of verbal intelligence quotient, freedom from distractibility, and executive function were observed in epilepsy group. Interestingly, poor performance in these cognitive subdomains was correlated with regional VBM findings involving both GM and WM volumes, but with different patterns between groups. GM volumes revealed clear differences predominantly in the bilateral frontal regions. These findings indicate that certain cognitive functions may be affected in the early stage of epilepsy, not related to the long-standing epilepsy or medication, but more related to the neurocognitive developmental process in this age. Epilepsy can lead to neuroanatomical alterations in both GM and WM, which may affect cognitive functions, during early stages even before commencement of AED medication.
DOI
10.1155/2015/923861
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
001.pdf(4.31 MB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE