View : 144 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author윤혜전-
dc.date.accessioned2016-08-27T04:08:10Z-
dc.date.available2016-08-27T04:08:10Z-
dc.date.issued2016-
dc.identifier.issn0938-7994-
dc.identifier.issn1432-1084-
dc.identifier.otherOAK-15660-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/217622-
dc.description.abstractTo prospectively compare performances of single-voxel proton magnetic resonance spectroscopy (H-1-MRS) and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pathologic response to neoadjuvant chemotherapy (NAC) in breast cancer patients. Thirty-five breast cancer patients who received NAC and subsequent surgery were prospectively enrolled. MRS and FDG-PET were performed before and after the 1st NAC cycle. Percentage changes of total choline-containing compounds (tCho) via MRS, and maximum and peak standardized uptake values (SUVmax, SUVpeak) and total lesion glycolysis (TLG) via FDG-PET were measured, and their performances in predicting pathologic complete response (pCR) were compared. Of the 35 patients, 6 showed pCR and 29 showed non-pCR. Mean % reductions of tCho, SUVmax, SUVpeak, and TLG of the pCR group were larger than those of the non-pCR group (-80.3 +/- 13.9 % vs. -32.1 +/- 49.4 %, P = 0.025; -54.7 +/- 22.1 % vs. -26.3 +/- 33.7 %, P = 0.058; -60.7 +/- 18.3 % vs. -32.3 +/- 23.3 %, P = 0.009; -89.5 +/- 8.5 % vs. -52.6 +/- 36.2 %, P = 0.020). Diagnostic accuracy (area under ROC curve; Az, 0.911) of the % reduction of tCho was comparable to those of %SUVmax (0.822), SUVpeak (0.862), and TLG (0.879) in distinguishing pCR from non-pCR (all P > 0.05). MRS showed comparable performance to FDG-PET in early prediction of pCR in breast cancer patients. aEuro cent MRS can predict response to NAC in breast cancer post-1 (st) cycle. aEuro cent Changes in tCho and SUV after NAC reflect tumour cellularity changes. aEuro cent MRS can be an alternative to FDG-PET in predicting response to NAC.-
dc.languageEnglish-
dc.publisherSPRINGER-
dc.subjectBreast neoplasm-
dc.subjectMagnetic resonance imaging-
dc.subjectMagnetic resonance spectroscopy-
dc.subjectPositron emission tomography-
dc.subjectNeoadjuvant chemotherapy-
dc.titleEarly prediction of response to neoadjuvant chemotherapy in breast cancer patients: comparison of single-voxel H-1-magnetic resonance spectroscopy and F-18-fluorodeoxyglucose positron emission tomography-
dc.typeArticle-
dc.relation.issue7-
dc.relation.volume26-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2279-
dc.relation.lastpage2290-
dc.relation.journaltitleEUROPEAN RADIOLOGY-
dc.identifier.doi10.1007/s00330-015-4014-7-
dc.identifier.wosidWOS:000377996200034-
dc.identifier.scopusid2-s2.0-84941670486-
dc.author.googleCho, Nariya-
dc.author.googleIm, Seock-Ah-
dc.author.googleKang, Keon Wook-
dc.author.googlePark, In-Ae-
dc.author.googleSong, In Chan-
dc.author.googleLee, Kyung-Hun-
dc.author.googleKim, Tae-Yong-
dc.author.googleLee, Hyunjong-
dc.author.googleChun, In Kook-
dc.author.googleYoon, Hai-Jeon-
dc.author.googleMoon, Woo Kyung-
dc.contributor.scopusid윤혜전(47161772300)-
dc.date.modifydate20191114141602-
Appears in Collections:
의료원 > 의료원 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE