View : 42 Download: 4

Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease

Title
Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease
Authors
Kim, JoohaeYoon, Ho IlOh, Yeon-MokLim, Seong YongLee, Ji-HyunKim, Tae-HyungLee, Sang YeubLee, Jin HwaLee, Sang-DoLee, Chang-Hoon
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2015
Journal Title
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
ISSN
1178-2005JCR Link
Citation
vol. 10
Keywords
annual lung function declinechronic obstructive pulmonary diseaseGOLD 2014
Publisher
DOVE MEDICAL PRESS LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background: Since the Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups A-D were introduced, the lung function changes according to group have been evaluated rarely. Objective: We investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines. Methods: Patients with COPD included in the Korean Obstructive Lung Disease (KOLD) prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1), which was analyzed by random-slope and random-intercept mixed linear regression. Results: A total 175 participants were included. No significant postbronchodilator FEV1 decline was observed between the groups (-34.4 +/- 7.9 [group A]; -26.2 +/- 9.4 [group B]; -22.7 +/- 16.0 [group C]; and -24.0 +/- 8.7 mL/year [group D]) (P=0.79). The group with less symptoms (-32.3 +/- 7.2 vs -25.0 +/- 6.5 mL/year) (P=0.44) and the low risk group (-31.0 +/- 6.1 vs -23.6 +/- 7.7 mL/year) (P=0.44) at baseline showed a more rapid decline in the postbronchodilator FEV1, but the trends were not statistically significant. However, GOLD stages classified by FEV1 were significantly related to the annual lung function decline. Conclusion: There was no significant difference in lung function decline rates according to the GOLD groups. Prior classification using postbronchodilator FEV1 predicts decline in lung function better than does the new classification.
DOI
10.2147/COPD.S87766
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
001.pdf(347.86 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE