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The ER/PM microdomain, PI(4,5)P-2 and the regulation of STIM1-Orai1 channel function

Title
The ER/PM microdomain, PI(4,5)P-2 and the regulation of STIM1-Orai1 channel function
Authors
Cao, XuChoi, SeokMaleth, Jozsef J.Park, SeongheeAhuja, MaliniMuallem, Shmuel
Ewha Authors
박성희
SCOPUS Author ID
박성희scopus
Issue Date
2015
Journal Title
CELL CALCIUM
ISSN
0143-4160JCR Link1532-1991JCR Link
Citation
vol. 58, no. 4, pp. 342 - 348
Keywords
ER/PM microdomainsCalcium signalingStim1Orai1
Publisher
CHURCHILL LIVINGSTONE
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
All forms of cell signaling occur in discreet cellular microdomains in which the ER is the main participant and include microdomains formed by the ER with lysosomes, endosomes, the nucleus, mitochondria and the plasma membrane. In the microdomains the two opposing organelles transfer and exchange constituents including lipids and ions. As is the case for other forms of signaling pathways, many components of the receptor-evoked Ca2+ signal are clustered at the ER/PM microdomain, including the Orai1-STIM1 complex. This review discusses recent advances in understanding the molecular components that tether the ER and plasma membrane to form the ER/PM microdomains in which PI(4,5)P-2 is enriched, and how dynamic targeting of the Orai1-STIM1 complex to PI(4,5)P-2-poor and PI(4,5)P-2-rich microdomains controls the activity of Orai1 and its regulation by Ca2+ that is mediated by SARAF. Published by Elsevier Ltd.
DOI
10.1016/j.ceca.2015.03.003
Appears in Collections:
의과대학 > 의학과 > Journal papers
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