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The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
- The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
- Ban, Yeon Hee; Park, Sung Ryeol; Yoon, Yeo Joon
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- 1367-5435; 1476-5535
- vol. 43, no. 42403, pp. 389 - 400
- FK506; Biological activity; Biosynthetic pathway; Production improvement; FK506 analogs; Genetic engineering
- SPRINGER HEIDELBERG
- SCI; SCIE; SCOPUS
- FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.
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