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The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

Title
The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects
Authors
Ban, Yeon HeePark, Sung RyeolYoon, Yeo Joon
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2016
Journal Title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN
1367-5435JCR Link1476-5535JCR Link
Citation
vol. 43, no. 42403, pp. 389 - 400
Keywords
FK506Biological activityBiosynthetic pathwayProduction improvementFK506 analogsGenetic engineering
Publisher
SPRINGER HEIDELBERG
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.
DOI
10.1007/s10295-015-1677-7
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자연과학대학 > 화학·나노과학전공 > Journal papers
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