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Functional immune responses to twelve serotypes after immunization with a 23-valent pneumococcal polysaccharide vaccine in older adults

Title
Functional immune responses to twelve serotypes after immunization with a 23-valent pneumococcal polysaccharide vaccine in older adults
Authors
Ahn, Jong GyunKim, Han WoolChoi, Hee JungLee, Jin HwaKim, Kyung-Hyo
Ewha Authors
김경효이진화최희정김한울안종균
SCOPUS Author ID
김경효scopus; 이진화scopus; 최희정scopus; 김한울scopus; 안종균scopus
Issue Date
2015
Journal Title
VACCINE
ISSN
0264-410XJCR Link1873-2518JCR Link
Citation
vol. 33, no. 38, pp. 4770 - 4775
Keywords
Pneumococcal polysaccharide vaccineImmunogenicityOpsoninPhagocytosisElderly
Publisher
ELSEVIER SCI LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Background: The 23-valent pneumococcal polysaccharide vaccine (PPSV23) was introduced as part of the national immunization program for the elderly (>= 65 years of age) in Korea on 2013. To evaluate immune responses in this population, serotype-specific anti-pneumococcal antibodies were studied with opsonophagocytic assay (OPA). Methods: Pneumococcal vaccine-naive participants >= 65 years of age were enrolled. They were divided into two groups according to their age: 30 in (65-74 years) and 32 in group (>= 75 years). The functional antibody response was determined by multiplexed OPA (MOPA) for 12 serotypes (1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F) before and 4 weeks after vaccination with PPSV23. Results: Geometric mean titers (GMTs) to all tested serotypes significantly increased in both groups after vaccination compared to those before vaccination. There were no significant differences in either the fold rise (post-vaccination to pre-vaccination) or the percentage of participants with a >= 4-fold increase in OPA titers between two groups for any of the 12 serotypes. Following vaccination, GMT for serotype 9V was higher in group 1 than in group 2 (P=0.011). Conclusions: PPSV23 induces functional immune response for 12 vaccine serotypes in both age groups. Further analysis is needed for the remaining 11 serotypes in the PPSV23, in order to develop a better understanding of the immune responses induced by PPV23 in older adults. (C) 2015 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.vaccine.2015.08.002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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