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Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study
- Title
- Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study
- Authors
- Kim, Sangha; Kim, Min Ji; Kim, Seonwoo; Kang, Hyo Shin; Lim, Shin Won; Myung, Woojae; Lee, Yunhwan; Hong, Chang Hyung; Choi, Seong Hye; Na, Duk L.; Seo, Sang Won; Ku, Bon D.; Kim, Seong Yoon; Kim, Sang Yun; Jeong, Jee Hyang; Park, Sun Ah; Carroll, Bernard J.; Kim, Doh Kwan
- Ewha Authors
- 정지향
- SCOPUS Author ID
- 정지향
- Issue Date
- 2015
- Journal Title
- COMPREHENSIVE PSYCHIATRY
- ISSN
- 0010-440X
1532-8384
- Citation
- COMPREHENSIVE PSYCHIATRY vol. 62, pp. 114 - 122
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Indexed
- SCI; SCIE; SSCI; SCOPUS
- Document Type
- Article
- Abstract
- Background: Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods: Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results: Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE epsilon 4 alleles were the significant risk factors. Conclusions: Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI. (C) 2015 Elsevier Inc. All rights reserved.
- DOI
- 10.1016/j.comppsych.2015.07.002
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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