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Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study

Title
Gender differences in risk factors for transition from mild cognitive impairment to Alzheimer's disease: A CREDOS study
Authors
Kim, SanghaKim, Min JiKim, SeonwooKang, Hyo ShinLim, Shin WonMyung, WoojaeLee, YunhwanHong, Chang HyungChoi, Seong HyeNa, Duk L.Seo, Sang WonKu, Bon D.Kim, Seong YoonKim, Sang YunJeong, Jee HyangPark, Sun AhCarroll, Bernard J.Kim, Doh Kwan
Ewha Authors
정지향
SCOPUS Author ID
정지향scopus
Issue Date
2015
Journal Title
COMPREHENSIVE PSYCHIATRY
ISSN
0010-440XJCR Link1532-8384JCR Link
Citation
vol. 62, pp. 114 - 122
Publisher
W B SAUNDERS CO-ELSEVIER INC
Indexed
SCI; SCIE; SSCI; SCOPUS WOS scopus
Abstract
Background: Women are subject to a disproportionate burden from Alzheimer's disease (AD) and sex differences exist in treatment response and prognosis of the disease. Yet gender-specific risk factors have not been widely studied. We aimed to investigate gender-specific risk factors for AD in subjects with mild cognitive impairment (MCI). Methods: Participants (n = 294) with MCI were recruited from a nationwide, prospective cohort study of dementia and were followed for a median (range) of 13.8 (6.0-36.0) months. Sex-stratified associations of progression to AD with baseline characteristics were explored. Results: Seventy-four individuals (25.2%) developed incident dementia (67 AD) during follow-up. Significant risk factors for probable AD differed by sex. In men, the significant risk factors were severe periventricular white matter hyperintensities, and poorer global cognitive function. In women, older age, clinically significant depressive symptoms at baseline, and positive APOE epsilon 4 alleles were the significant risk factors. Conclusions: Risk factors for progression from MCI to probable AD differed in men and women. These results may translate to gender-specific preventative or therapeutic strategies for patients with MCI. (C) 2015 Elsevier Inc. All rights reserved.
DOI
10.1016/j.comppsych.2015.07.002
Appears in Collections:
의과대학 > 의학과 > Journal papers
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