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GWA meta-analysis of personality in Korean cohorts

Title
GWA meta-analysis of personality in Korean cohorts
Authors
Kim, Bo-HyeKim, Han-NaRoh, Seung-JuLee, Mi KyeongYang, SarahLee, Seung KuSung, Yeon-AhChung, Hye WonCho, Nam H.Shin, CholSung, JoohonKim, Hyung-Lae
Ewha Authors
김형래성연아정혜원김한나
SCOPUS Author ID
김형래scopus; 성연아scopus; 정혜원scopus; 김한나scopus
Issue Date
2015
Journal Title
JOURNAL OF HUMAN GENETICS
ISSN
1434-5161JCR Link1435-232XJCR Link
Citation
vol. 60, no. 8, pp. 455 - 460
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Personality is a determinant of behavior and lifestyle that is associated with health and human diseases. Despite the heritability of personality traits is well established, the understanding of the genetic contribution to personality trait variation is extremely limited. To identify genetic variants associated with each of the five dimensions of personality, we performed a genome-wide association (GWA) meta-analysis of three cohorts, followed by comparison of a family cohort. Personality traits were measured with the Revised NEO Personality Inventory for the five-factor model (FFM) of personality. We investigated the top five single-nucleotide polymorphisms (SNPs) for each trait, and revealed the most highly association with neuroticism and TACC2 (rs1010657, P=8.79 x 10(-7)), extraversion and PTPN12 (rs12537271, P=1.47 x 10(-7)), openness and IMPAD1 (rs16921695, P=5x10(-8)), agreeableness and RPS29 (rs8015351, P=1.27 x 10(-6)) and conscientiousness and LMO4 (rs912765, P=2.91 x 10(-6)). It had no SNP reached the GWA study threshold (P<5x10(-8)). When expanded the SNPs up to top 100, the correlation of PTPRD (rs1029089) and agreeableness was confirmed in Healthy Twin cohort with other 13 SNPs. This GWA meta-analysis on FFM personality traits is meaningful as it was the first on a non-Caucasian population targeted to FFM of personality traits.
DOI
10.1038/jhg.2015.52
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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