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Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

Title
Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients
Authors
Lee, Mi JungLee, Sul A.Nam, Bo YoungPark, SunghaLee, Sang-HakRyu, Han JakKwon, Young EunKim, Yung LyPark, Kyoung SookOh, Hyung JungPark, Jung TakHan, Seung HyeokRyu, Dong-RyeolKang, Shin-WookYoo, Tae-Hyun
Ewha Authors
류동열
SCOPUS Author ID
류동열scopus
Issue Date
2015
Journal Title
ATHEROSCLEROSIS
ISSN
0021-9150JCR Link1879-1484JCR Link
Citation
vol. 242, no. 2, pp. 476 - 482
Keywords
Carotid atherosclerosisIrisinMyokinePeritoneal dialysisSarcopenia
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objective: In end-stage renal disease, deleterious effect of sarcopenia on cardiovascular disease has been explained mainly by chronic inflammation. However, evidence emerged that skeletal muscles mediate their protective effect against sarcopenia by secreting myokines. Therefore, we sought to investigate the effect of irisin, a recently introduced myokine, on the association between sarcopenia and cardiovascular disease in peritoneal dialysis (PD) patients. Methods: Serum irisin concentrations were assessed by enzyme-linked immunosorbent assay in 102 prevalent PD patients and 35 age- and sex-matched controls. To determine sarcopenia and cardiovascular disease, anthropometric indices including mid-arm muscle circumference (MAMC) and carotid intima-media thickness (cIMT) were measured. Results: Serum irisin concentrations were significantly lower in PD patients than in controls (184.2 +/- 88.0 vs. 457.2 +/- 105.5 ng/mL, P < 0.001). In PD patients, univariate linear regression analysis showed that serum irisin was positively correlated with MAMC and thigh circumference, but negatively correlated with residual renal function and cIMT. Multivariate analysis revealed that MAMC (per 1 cm increase, B = 8.78, 95% confidence interval [CI] = 0.77-16.79, P = 0.03) had an independent association with serum irisin. In addition, serum irisin was a significant independent predictor for carotid atherosclerosis even after adjustment for high-sensitivity C-reactive protein in PD patients (per 1 g/mL increase, odds ratio = 0.990, 95% CI = 0.982-0.997, P = 0.007). Conclusion: This study demonstrated that serum irisin was significantly associated with sarcopenia and carotid atherosclerosis in PD patients. Additional studies to provide a confirmation and examine possible mechanisms are warranted. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.atherosclerosis.2015.08.002
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의학전문대학원 > 의학과 > Journal papers
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